|
Anxiety
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in genes coding for the serotonin receptor subtype 1A (HTR1A), the serotonin transporter (SLC6A4), and the serotonin degrading enzyme monoamine oxidase A (MAOA) are associated with anxiety, impulsivity, and neurotic personality in humans.
|
31045220 |
2019 |
|
Anxiety
|
0.100 |
Biomarker
|
disease |
BEFREE |
The selective serotonin reuptake inhibitor fluoxetine and the 5-HT1A receptor agonist buspirone are used to treat depression and anxiety.
|
31244623 |
2019 |
|
Anxiety
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that markedly reduced 5-HT1A autoreceptors may provide a marker for aberrant response to SSRI treatment.<b>SIGNIFICANCE STATEMENT</b> Serotonin-selective reuptake inhibitors (SSRIs) are effective in treating anxiety and depression in humans and mouse models.
|
30552180 |
2019 |
|
Anxiety
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We thus conducted a structural equation model (SEM) to examine whether the HTR1A rs6295 variant can affect anxiety by altering parasympathetic nervous activity.
|
29363117 |
2018 |
|
Anxiety
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Targeting specific transcription factors, such as Freud-1, to restore transcriptional balance may augment response to antidepressant treatment.<b>SIGNIFICANCE STATEMENT</b> Altered regulation of the 5-HT1A autoreceptor has been implicated in human anxiety, major depression, suicide, and resistance to antidepressants.
|
29101244 |
2017 |
|
Anxiety
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
electronic database was used as source of the studies selected selected based on the studies found by crossing the following keywords: cannabidiol and panic disorder; canabidiol and anxiety, cannabidiol and 5-HT1A receptor).
|
27157263 |
2017 |
|
Anxiety
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim was to further characterize the impact of cue acquisition and trait anxiety, and of a single nucleotide polymorphism in the serotonin 1A receptor gene (5-HTR1A, rs6295), on cued fear and contextual anxiety before and after fear contingencies were explicitly introduced.
|
25448266 |
2015 |
|
Anxiety
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Transcriptional dys-regulation in anxiety and major depression: 5-HT1A gene promoter architecture as a therapeutic opportunity.
|
24180393 |
2014 |
|
Anxiety
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this review, we examine the function of 5-HT(1A) receptor subpopulations and re-interpret our understanding of their role in mental illness in light of new data, separating both spatial (autoreceptor versus heteroreceptor) and the temporal (developmental versus adult) roles of the endogenous 5-HT(1A) receptors, emphasizing their distinct actions in mediating anxiety and depression-like behaviors.
|
24337875 |
2014 |
|
Anxiety
|
0.100 |
Biomarker
|
disease |
BEFREE |
This work indicates that the effects of 5-HT1A autoreceptors on anxiety and social behaviors are developmentally mediated and suggests that natural variations in the expression of 5-HT1A may act during development to influence individual anxiety levels and contribute to susceptibility to anxiety disorders.
|
23907404 |
2014 |
|
Anxiety
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Targeted therapeutics to inhibit 5-HT(1A) autoreceptor expression and induce 5-HT(1A) heteroreceptor expression may ameliorate treatment of anxiety and major depression.
|
22826341 |
2012 |
|
Anxiety
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the possible association between depression and anxiety scores and SNPs within the HTR1A and HTR1B genes in a population sample (n=1387).
|
20638825 |
2011 |
|
Anxiety
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Only the G allele of HTR1A rs6295 seemed to increase the risk of emotional-dramatic cluster B personality disorders (p = 0.019, in the personality disorder sample) and to decrease the risk of anxious-fearful cluster C personality disorders (p = 0.016, in the aADHD sample).
|
19894072 |
2010 |
|
Anxiety
|
0.100 |
Biomarker
|
disease |
BEFREE |
The 5-HT(1A) receptor is a metabotropic G protein-coupled receptor linked to the G(i/o) signaling pathway and has been specifically implicated in the pathogenesis of depression and anxiety.
|
20643652 |
2010 |
|
Anxiety
|
0.100 |
Biomarker
|
disease |
BEFREE |
In healthy subjects, increased anxiety scores might be associated with lower 5-HT1A receptor binding.
|
19423077 |
2009 |
|
Anxiety
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Altered expression of serotonin-1A (5-HT1A) receptors, both presynaptic in the raphe nuclei and post-synaptic in limbic and cortical target areas, has been implicated in mood disorders such as major depression and anxiety.
|
19423080 |
2009 |
|
Anxiety
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings further implicate relatively increased serotonin signaling, associated with a genetic variation that mediates increased 5-HT(1A) autoreceptors, in driving amygdala reactivity and trait anxiety.
|
19124686 |
2009 |
|
Anxiety
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As such, the level of expression of 5-HT1A receptors is implicated in the development of anxiety and depression phenotypes.
|
18639564 |
2008 |
|
Anxiety
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we examined the serotonin 1A receptor gene, HTR1A, for its association with shared genetic risk across a range of anxiety and depression-related phenotypes.
|
18163385 |
2008 |
|
Anxiety
|
0.100 |
Biomarker
|
disease |
BEFREE |
While multiple lines of evidence implicate the 5-HT1A receptor in the pathophysiology of anxiety and depression as well as in the mechanism of action of anxiolytics/antidepressants, its relevance to the therapeutic effectiveness of these drugs has been a matter of considerable debate (for review see Griebel, 1995; Hensler, 2003; Hjorth et al., 2000; Lesch et al., 2003).
|
15683551 |
2004 |
|
Anxiety
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A functional promoter polymorphism in the serotonin receptor 1A (5-HT1A) gene has been found to be associated with major depression as well as anxiety- and depression-related personality traits.
|
14984628 |
2004 |
|
Anxiety
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our findings indicate a role of allelic variation in 5-HT1A receptor expression in the development and modulation of anxiety- and depression-related personality traits.
|
14666415 |
2003 |
|
Anxiety
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this paper, studies focusing on anxiety using 5-HT1A receptor knockout (1AKO) and 5-HT1B receptor knockout (1BKO) mice are reviewed.
|
14501251 |
2003 |
|
Anxiety
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice lacking the 5-HT1A have been found to be more anxious in several behavioral paradigms.
|
11374326 |
2001 |
|
Anxiety
|
0.100 |
Biomarker
|
disease |
BEFREE |
The serotonin system, and the serotonin(1A) (5-HT(1A)) receptor in particular, have been under intense investigation, mostly due to the fact that serotonergic drugs that directly or indirectly affect the 5-HT(1A) receptor, are effective therapeutic agents in treating patients with various neuropsychiatric disorders, including anxiety and depression.
|
11704418 |
2001 |