|
Mental disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
As a result, genetic mechanisms that modulate human 5-HT1A levels may be important for explaining individual differences in mood and behavior, representing a potential source of psychiatric disease risk.
|
30694044 |
2019 |
|
Mental disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that the metaplastic 5-HTergic mechanism via 5-HT1A receptors in the MRN-hippocampus pathway is a key component for gender-specific emotional regulation and may be a cause of psychiatric disorders associated with vulnerability or resistance to emotional stress.
|
24599137 |
2014 |
|
Mental disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
In this review, we examine the function of 5-HT(1A) receptor subpopulations and re-interpret our understanding of their role in mental illness in light of new data, separating both spatial (autoreceptor versus heteroreceptor) and the temporal (developmental versus adult) roles of the endogenous 5-HT(1A) receptors, emphasizing their distinct actions in mediating anxiety and depression-like behaviors.
|
24337875 |
2014 |
|
Mental disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Transcriptional regulation of the 5-HT1A receptor: implications for mental illness.
|
22826341 |
2012 |
|
Mental disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Several investigations have reported associations between serotonin 1A (5-HT1A) receptor and major psychiatric disorders, such as schizophrenia and bipolar disorder (BP), making the 5-HT1A receptor gene (HTR1A) a good candidate gene for the pathophysiology of schizophrenia and BP.
|
20594600 |
2011 |
|
Mental disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness.
|
21619616 |
2011 |
|
Mental disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
There are conflicting reports of an association between a common functional single nucleotide polymorphism (rs6295C/G) in the serotonin-1A receptor gene (HTR1A) and psychological disorders.
|
19997044 |
2010 |
|
Mental disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Finally, association of the G(-1019) allele with increased raphe 5-HT1A binding potential, increased amygdala reactivity to emotional stimuli, and reduced amygdala volume, particularly in disease states, suggests a functional role for the C(-1019)G site in 5-HT1A receptor dys-regulation and predisposition to mental illness.
|
18639564 |
2008 |
|
Mental disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Findings in the literature are not consistent with any definite 5-HT1A influence in psychiatric disorders.
|
18047755 |
2008 |
|
Mental disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Alterations in 5-HT(1A,) 5-HT(1B), and 5-HT(2A) mRNA levels in the brains of subjects with both mood disorders and schizophrenia add further support for hypothesis of dysregulation of the serotonergic system in these psychiatric disorders.
|
14744462 |
2004 |
|
Mental disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The association with major depression, suicide, and panic disorder of a new functional 5-HT1A polymorphism at C(-1019)G that selectively blocks repression of the 5-HT1A autoreceptor by NUDR further suggests a causative role for altered regulation of this receptor in predisposition to mental illness.
|
15534042 |
2004 |