HTR1B, 5-hydroxytryptamine receptor 1B, 3351

N. diseases: 140; N. variants: 9
Disease: Anxiety Disorders ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.230 AlteredExpression group BEFREE 5-HT1B knockout mice display hyperactivity, increased exploratory activity and aggression, reduced anxiety, increased vulnerability to cocaine self-administration, and elevated alcohol consumption. 15578608 2005
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.230 Biomarker group BEFREE In this paper, studies focusing on anxiety using 5-HT1A receptor knockout (1AKO) and 5-HT1B receptor knockout (1BKO) mice are reviewed. 14501251 2003
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.230 Biomarker group RGD Because these tests are sensitive to increases in anxiety-like behavior, our results suggest that overactivity of 5-HT(1B) autoreceptors in DRN neurons may be an important mediator of pathological responses to stressful events. 12040062 2002
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.230 AlteredExpression group BEFREE Overexpression of 5-HT1B receptor in dorsal raphe nucleus using Herpes Simplex Virus gene transfer increases anxiety behavior after inescapable stress. 12040062 2002