HTR1B, 5-hydroxytryptamine receptor 1B, 3351

N. diseases: 140; N. variants: 9
Disease: Cocaine Abuse ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.500 Biomarker disease PSYGENET This unique pattern of effects suggests that mesolimbic 5-HT(1B)Rs differentially modulate cocaine abuse-related behaviors, with a facilitative influence during periods of active drug use, in striking contrast to an inhibitory influence during protracted withdrawal. 22541946 2012
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.500 Biomarker disease CTD_human 5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine. 17509084 2007
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.500 Therapeutic disease CTD_human 5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine. 17509084 2007
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.500 Biomarker disease CTD_human Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. 9603521 1998
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.500 Therapeutic disease CTD_human Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. 9603521 1998