HTR1B, 5-hydroxytryptamine receptor 1B, 3351

N. diseases: 140; N. variants: 9
Disease: Depressive disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 GeneticVariation disease BEFREE Whether CTX and P1NP changes were associated with depression remission and duration of depression and genetic polymorphisms in the serotonin transporter (5HTTLPR) and 1B receptor (HTR1B) were also examined. 28555718 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease BEFREE Our findings suggested that p11 might be a potential regulator on 5-HTR1b and 5-HTR4 as well as a predictor of or a therapeutic target for IFN-α-induced depression. 26821757 2016
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease PSYGENET This study aimed at investigating the roles of the 5-HT(1B)R, and its adapter protein p11, in emotional memory and object recognition memory processes by the use of p11 knockout (p11KO) mice, a genetic model for aspects of depression-related states. 23032875 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease PSYGENET We sought to study the relationship of Rgs2 expression level to depression and anxiety-like behavioural features, sociability and brain 5-HT1A and 5-HT1B receptor expression. 22040681 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease PSYGENET Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response. 21937687 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease PSYGENET Genes that have been previously associated with depression, AD, or other addiction-related phenotypes - such as CDH13, CSMD2, GRID1, and HTR1B - were implicated by nominally significant SNPs. 22064162 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease PSYGENET In the NEWMOOD cohort polymorphisms of the genes of the serotonin transporter, 5-HT1A, 5-HT1B and 5-HT2A and endocannabinoid CB1 receptors, tryptophan hydroxylase, CREB1, BDNF and GIRK provide evidence for the involvement of these genes in the development of depression. 23269207 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease BEFREE We investigated the possible association between depression and anxiety scores and SNPs within the HTR1A and HTR1B genes in a population sample (n=1387). 20638825 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease BEFREE SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A. 19829169 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease BEFREE 5-HT(1B) receptor agonists administered alone or with antidepressants have been shown to be effective in preclinical models of depression. 19702551 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease BEFREE We have found that the serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. 16400147 2006