Major Depressive Disorder
|
0.360 |
Biomarker
|
disease |
BEFREE |
The evidence outlined range from animal models of disease, effects of 5-HT1B receptor agonists and antagonists, case-control studies of 5-HT1B receptor binding postmortem and in vivo, with positron emission tomography, to clinical studies of 5-HT1B receptor effects of established treatments for MDD.
|
29546551 |
2018 |
Major Depressive Disorder
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
The rs6296-C allele lowered the level of HTR1B mRNA, causing individuals with MDD to display more hostility and aggressive behavior, which may lead to suicidal ideation.
|
28007644 |
2017 |
Major Depressive Disorder
|
0.360 |
Biomarker
|
disease |
PSYGENET |
In total, 14 single nucleotide polymorphisms (SNPs) in coding regions of 10 serotonergic genes (HTR1A, HTR1B, HTR1D, HTR2A, HTR3A, HTR3C, HTR3D, HTR3E, HTR5A and TPH2) were genotyped in 308 Chinese Han patients with major depressive disorder.
|
21937687 |
2012 |
Major Depressive Disorder
|
0.360 |
Biomarker
|
disease |
PSYGENET |
The etiology of major depression remains unknown, but dysfunction of serotonergic signaling has long been implicated in the pathophysiology of this disorder. p11 is an S100 family member recently identified as a serotonin 1B [5-hydroxytryptamine 1B (5-HT(1B))] and serotonin 4 (5-HT(4)) receptor-binding protein.
|
20962330 |
2010 |
Major Depressive Disorder
|
0.360 |
Biomarker
|
disease |
BEFREE |
Our work indicated that the HTR1B gene might be involved in the development of suicidal ideation in MD among a Chinese Han population.
|
19897250 |
2009 |
Major Depressive Disorder
|
0.360 |
Biomarker
|
disease |
PSYGENET |
Our work indicated that the HTR1B gene might be involved in the development of suicidal ideation in MD among a Chinese Han population.
|
19897250 |
2009 |
Major Depressive Disorder
|
0.360 |
Biomarker
|
disease |
BEFREE |
An abundance of research suggests that several 5-HT receptor subtypes may be dysfunctional in patients with MDD including the 5-HT(1B) receptor.
|
19702551 |
2009 |
Major Depressive Disorder
|
0.360 |
Biomarker
|
disease |
PSYGENET |
An abundance of research suggests that several 5-HT receptor subtypes may be dysfunctional in patients with MDD including the 5-HT(1B) receptor.
|
19702551 |
2009 |
Major Depressive Disorder
|
0.360 |
Biomarker
|
disease |
PSYGENET |
Our findings suggest that 5-HT1B A-161T genetic polymorphism does not play a major role in the susceptibility to MDD, nor is it related to suicidal attempt or the therapeutic response to fluoxetine in MDD.
|
15365222 |
2004 |
Major Depressive Disorder
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that 5-HT1B A-161T genetic polymorphism does not play a major role in the susceptibility to MDD, nor is it related to suicidal attempt or the therapeutic response to fluoxetine in MDD.
|
15365222 |
2004 |
Major Depressive Disorder
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism.
|
12496953 |
2003 |