|
Cocaine Abuse
|
0.500 |
Biomarker
|
disease |
PSYGENET |
This unique pattern of effects suggests that mesolimbic 5-HT(1B)Rs differentially modulate cocaine abuse-related behaviors, with a facilitative influence during periods of active drug use, in striking contrast to an inhibitory influence during protracted withdrawal.
|
22541946 |
2012 |
|
Cocaine Dependence
|
0.500 |
Biomarker
|
disease |
PSYGENET |
These findings suggest that targeting 5-HT(1B)Rs may lead to a novel treatment for cocaine dependence and that the therapeutic efficacy of these treatments may vary depending on the stage of the addiction cycle.
|
22541946 |
2012 |
|
Cocaine Abuse
|
0.500 |
Biomarker
|
disease |
CTD_human |
5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine.
|
17509084 |
2007 |
|
Cocaine Abuse
|
0.500 |
Therapeutic
|
disease |
CTD_human |
5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine.
|
17509084 |
2007 |
|
Cocaine Dependence
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Thus, 5-HT(1B) mRNA is upregulated by repeated exposure to cocaine and perhaps by social stress as well; both of these factors are relevant to the risk for relapse in cocaine addiction.
|
17059838 |
2007 |
|
Cocaine Dependence
|
0.500 |
Therapeutic
|
disease |
CTD_human |
5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine.
|
17509084 |
2007 |
|
Cocaine Dependence
|
0.500 |
Biomarker
|
disease |
CTD_human |
5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine.
|
17509084 |
2007 |
|
Cocaine Abuse
|
0.500 |
Biomarker
|
disease |
CTD_human |
Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor.
|
9603521 |
1998 |
|
Cocaine Abuse
|
0.500 |
Therapeutic
|
disease |
CTD_human |
Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor.
|
9603521 |
1998 |
|
Cocaine Dependence
|
0.500 |
Therapeutic
|
disease |
CTD_human |
Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor.
|
9603521 |
1998 |
|
Cocaine Dependence
|
0.500 |
Biomarker
|
disease |
CTD_human |
Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor.
|
9603521 |
1998 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Serotonergic changes have been associated with alcoholism, while serotonin receptors type 1B (5-HT1B) play an important role in regulating serotonergic neurotransmission.
|
30774345 |
2019 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our findings point to an association between functional variants in the promoter region of the HTR1B gene and alcohol dependence, supporting previous neurobiological evidences of the involvement of HTR1B variations in alcohol-related phenotypes.
|
22005095 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Genes that have been previously associated with depression, AD, or other addiction-related phenotypes - such as CDH13, CSMD2, GRID1, and HTR1B - were implicated by nominally significant SNPs.
|
22064162 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that neither the 5-HTTLPR gene nor the 5-HT1B G861C polymorphism alone is a risk factor for antisocial alcoholism in Taiwan's Han Chinese population, but that the interaction between both genes may increase susceptibility to antisocial alcoholism.
|
22550993 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
PSYGENET |
In conclusion, our findings point to an association between functional variants in the promoter region of the HTR1B gene and alcohol dependence, supporting previous neurobiological evidences of the involvement of HTR1B variations in alcohol-related phenotypes.
|
22005095 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Our study suggests that neither the 5-HTTLPR gene nor the 5-HT1B G861C polymorphism alone is a risk factor for antisocial alcoholism in Taiwan's Han Chinese population, but that the interaction between both genes may increase susceptibility to antisocial alcoholism.
|
22550993 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition, markers in the HTR1B and OPRμ1 genes showed genetic associations with subgroups of alcohol dependence (ORs = 1.5-2.4).
|
21906503 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
PSYGENET |
In addition, markers in the HTR1B and OPRμ1 genes showed genetic associations with subgroups of alcohol dependence (ORs = 1.5-2.4).
|
21906503 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings confirm HTR1B as a susceptibility gene for alcohol dependence in the sample of Chinese Han population.
|
21172311 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
PSYGENET |
These findings confirm HTR1B as a susceptibility gene for alcohol dependence in the sample of Chinese Han population.
|
21172311 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We further explored correlation of this 5HT1B gene variant between anxiety-depression alcoholism (ANX/DEP ALC) and antisocial alcoholism (antisocial ALC) subgroups because of the high comorbidity of anxiety-depression, antisocial personality disorder, and AD.
|
19519719 |
2009 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A blunting of GH responses in abstinent AD men was observed only among those with the most common HTR1B promoter diplotype.
|
17217931 |
2007 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
Biomarker
|
disease |
BEFREE |
5-Hydroxytryptamine (serotonin)-1B receptors (HTR1B) may play an important role in psychiatric disorders and drug and alcohol dependence.
|
16344719 |
2006 |
|
Alcoholic Intoxication, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Yu, A.T. Cheng, Association study of novel human serotonin 5-HT(1B) polymorphisms with alcohol dependence in Taiwanese Han, Biol.
|
15698927 |
2005 |