Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Carriership of the variant alleles of the HTR2C polymorphisms rs518147, rs1414334, and HTR2C:c.1-142948(GT)n was associated with an increased risk of the metabolic syndrome (adjusted odds ratio [OR], 2.62 [95% confidence interval {CI}, 1.00-6.85]; OR, 4.09 [95% CI, 1.41-11.89]; and OR, 3.12 [95% CI, 1.13-8.16]), respectively.
|
17632216 |
2007 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
CTD_human |
Carriership of the variant alleles of the HTR2C polymorphisms rs518147, rs1414334, and HTR2C:c.1-142948(GT)n was associated with an increased risk of the metabolic syndrome (adjusted odds ratio [OR], 2.62 [95% confidence interval {CI}, 1.00-6.85]; OR, 4.09 [95% CI, 1.41-11.89]; and OR, 3.12 [95% CI, 1.13-8.16]), respectively.
|
17632216 |
2007 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
CTD_human |
Patients (n=134) were assessed for measures of obesity, other factors contributing to metabolic syndrome, and two genetic polymorphisms (5-HT(2C) receptor -759C/T and leptin -2548A/G).
|
18515891 |
2008 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
CTD_human |
The variants of HTR2C:c.1-142948(GT)n (odds ratio [OR], 1.69; 95% confidence interval [CI], 0.75-3.81) and rs1414334 (OR, 2.35; 95% CI, 0.96-5.77) were not significantly associated with the metabolic syndrome in the replication sample but did show significance in the pooled analysis (OR, 2.09; 95% CI, 1.12-3.91; and OR, 2.35; 95% CI, 1.19-4.62, respectively).
|
19142101 |
2009 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The variants of HTR2C:c.1-142948(GT)n (odds ratio [OR], 1.69; 95% confidence interval [CI], 0.75-3.81) and rs1414334 (OR, 2.35; 95% CI, 0.96-5.77) were not significantly associated with the metabolic syndrome in the replication sample but did show significance in the pooled analysis (OR, 2.09; 95% CI, 1.12-3.91; and OR, 2.35; 95% CI, 1.19-4.62, respectively).
|
19142101 |
2009 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No association was found between the HTR2C -759 C/T polymorphism and the metabolic syndrome.
|
20680028 |
2012 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association between HTR2C polymorphisms and metabolic syndrome in patients with schizophrenia treated with atypical antipsychotics.
|
21185157 |
2011 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
HTR2C polymorphisms, olanzapine-induced weight gain and antipsychotic-induced metabolic syndrome in schizophrenia patients: a meta-analysis.
|
25152019 |
2014 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A pharmacogenomic analysis revealed the presence of the 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled (HTR2C) -759C genotype which is related to increased risk for metabolic syndrome.
|
26359410 |
2016 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several genes showed strong evidence for an association with MetS in patients with schizophrenia, including the fat mass and obesity associated gene (FTO), leptin and leptin receptor genes (LEP, LEPR), methylenetetrahydrofolate reductase (MTHFR) gene and the serotonin receptor 2C gene (HTR2C).
|
26621002 |
2016 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study confirms a high prevalence of metabolic side effects with clozapine and suggests higher clozapine level and pharmacogenetic markers in CYP2C19, LEP, LEPR, and HTR2C receptors as important predictors of BMI and metabolic syndrome.
|
27681143 |
2017 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
An association has been found between the C allele of the rs1414334 polymorphism in the HTR2C gene and the metabolic syndrome in psychiatric patients.
|
28492956 |
2018 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found associations with outcomes such as increases in BMI and metabolic syndrome for variants in genes such as LEP and HTR2C.
|
28879574 |
2017 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, HTR2C genetic variants may be involved in the susceptibility to MS in patients treated with atypical antipsychotics.
|
29441581 |
2018 |