HTR3A, 5-hydroxytryptamine receptor 3A, 3359

N. diseases: 75; N. variants: 5
Disease: Nausea and vomiting ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027498
Disease: Nausea and vomiting
Nausea and vomiting 		0.020 Biomarker phenotype BEFREE The 5-HT(3)-receptor antagonist ondansetron, commonly used to treat nausea and vomiting, was suspected of triggering malignant hyperthermia (MH) when a 5-year-old boy died after receiving a therapeutic dose of ondansetron. 22696611 2012
CUI: C0027498
Disease: Nausea and vomiting
Nausea and vomiting 		0.020 GeneticVariation phenotype BEFREE We included 242 cancer patients at their first day of chemotherapy to investigate the influence of genetic polymorphisms of the 5-HT3A receptor gene on the intensity of nausea and vomiting which was documented using standardized interviews and visual analog scales. 15115912 2004