HTR3A, 5-hydroxytryptamine receptor 3A, 3359

N. diseases: 75; N. variants: 5
Disease: Nicotine Dependence ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028043
Disease: Nicotine Dependence
Nicotine Dependence 		0.030 GeneticVariation disease BEFREE Further, a significant genetic interactive effect affecting ND was detected among SNPs rs10160548 in HTR3A, and rs3758987, rs2276305, and rs1672717 in HTR3B (p = 0.0074). 30405098 2018
CUI: C0028043
Disease: Nicotine Dependence
Nicotine Dependence 		0.030 Biomarker disease BEFREE Previous studies have implicated genes encoding the 5-HT3AB receptors (HTR3A and HTR3B) and the serotonin transporter (SLC6A4), both independently and interactively, in alcohol (AD), cocaine (CD), and nicotine dependence (ND). 24590108 2014
CUI: C0028043
Disease: Nicotine Dependence
Nicotine Dependence 		0.030 Biomarker disease BEFREE We conclude that SLC6A4, HTR3A and HTR3B play a significant role in ND through genetic interactions. 23290502 2013