HTR3A, 5-hydroxytryptamine receptor 3A, 3359

N. diseases: 75; N. variants: 5
Disease: Obsessive-Compulsive Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		0.030 GeneticVariation disease BEFREE These results support that common HTR3 variants are involved in OCD and some of its clinical phenotypes. 27616601 2016
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		0.030 GeneticVariation disease BEFREE These findings indicate a role of common variants of the HTR3A-E genes in OCD and OCD-related phenotypes and further support the use of 5-HT3 receptor antagonists as novel treatment options. 23928294 2014
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		0.030 Biomarker disease BEFREE Apart from the standard treatment with serotonin reuptake inhibitors and behavioural therapy, a 5-HT(3) receptor antagonist has recently been shown to benefit some OCD patients, suggesting the 5-HT(3) receptor as a serotonergic candidate gene in the polygenic aetiology of OCD. 17259209 2007