HTR3A, 5-hydroxytryptamine receptor 3A, 3359

N. diseases: 75; N. variants: 5
Disease: Schizophrenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 GeneticVariation disease BEFREE The aim of the present study was to determine whether the 5-HTR3A gene C178T polymorphism is associated with antipsychotic-induced TD in Korean schizophrenia patients. 23126479 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 GeneticVariation disease BEFREE Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia. 22700043 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease PSYGENET We evaluated whether genetic variants in the serotonin receptors HTR3A (rs897692, rs1150226, rs1176724, rs2276302, rs3737457, rs897687 and rs1176713) and HTR3B (rs3758987, rs10502180, rs11606194, rs17116121, rs1176744, rs17116138, rs2276307, rs3782025 and rs1176761) were susceptibility components for suicidal behavior in 154 Caucasians schizophrenia subjects (20.1% of suicide attempters). 21184810 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 GeneticVariation disease BEFREE Our results suggest that HTR3A and HTR3B polymorphisms may not play a major role in the susceptibility for suicidal behavior in schizophrenia subjects. 21184810 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE Applying an endophenotype approach, we investigated a potential impact of the genes of the 5-HT3A and 5-HT3B subunits as well as the novel 5-HT3C, 5-HT3D, and 5-HT3E subunits on CPT performance in subjects with schizophrenia. 20356718 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease PSYGENET Applying an endophenotype approach, we investigated a potential impact of the genes of the 5-HT3A and 5-HT3B subunits as well as the novel 5-HT3C, 5-HT3D, and 5-HT3E subunits on CPT performance in subjects with schizophrenia. 20356718 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 GeneticVariation disease BEFREE Taken together, our results suggest that variants in the HTR3A receptor gene can play a role in the treatment outcome of clozapine in schizophrenia patients that are refractory or intolerant of typical antipsychotic therapy. 20168265 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE Few studies have, however, focused on the association between the therapeutic responses to atypical antipsychotics, such as risperidone, and polymorphisms of the 5-HT3 receptor, the only ionotropic ligand-gated serotonin receptor, even though there have been some genetic clues linking HTR3A and schizophrenia. 18622264 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 GeneticVariation disease BEFREE To determine the haplotype block structure in the genomic regions of HTR3A and HTR3B, and to examine whether genetic variations in the region show evidence of association with schizophrenia and affective disorder in the Japanese, we performed haplotype-based case-control analysis using 29 polymorphisms. 16487942 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.380 Biomarker disease BEFREE Further studies are needed to support the hypothesis that HTR3A may contribute to the schizophrenia in these patients. 11207027 2001