HTR3A, 5-hydroxytryptamine receptor 3A, 3359

N. diseases: 75; N. variants: 5
Disease: Abnormal behavior ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.040 GeneticVariation phenotype BEFREE This study shows that epigenetic modification of the 5-HT3A R is involved in the mechanism underlying the relationship between maltreatment in childhood and the severity of several psychiatric disorders in adulthood. 26350166 2016
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.040 GeneticVariation phenotype BEFREE Single nucleotide polymorphisms (SNPs) in the 5-HT3A serotonin receptor gene are associated with psychiatric disorders. 26701104 2015
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.040 Biomarker phenotype BEFREE Owing to their expression profile and physiological functions, 5-HT(3) receptors have been implicated in irritable bowel syndrome (IBS) and psychiatric disorders. 21345729 2011
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.040 GeneticVariation phenotype BEFREE Genetic variations in the serotonin receptor 3A (HTR3A) and 3B (HTR3B) genes, positioned in tandem on chromosome 11q23.2, have been shown to be associated with psychiatric disorders in samples of European ancestry. 16487942 2006