Schizophrenia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to determine whether the 5-HTR3A gene C178T polymorphism is associated with antipsychotic-induced TD in Korean schizophrenia patients.
|
23126479 |
2013 |
Schizophrenia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia.
|
22700043 |
2012 |
Schizophrenia
|
0.380 |
Biomarker
|
disease |
PSYGENET |
We evaluated whether genetic variants in the serotonin receptors HTR3A (rs897692, rs1150226, rs1176724, rs2276302, rs3737457, rs897687 and rs1176713) and HTR3B (rs3758987, rs10502180, rs11606194, rs17116121, rs1176744, rs17116138, rs2276307, rs3782025 and rs1176761) were susceptibility components for suicidal behavior in 154 Caucasians schizophrenia subjects (20.1% of suicide attempters).
|
21184810 |
2011 |
Schizophrenia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that HTR3A and HTR3B polymorphisms may not play a major role in the susceptibility for suicidal behavior in schizophrenia subjects.
|
21184810 |
2011 |
Schizophrenia
|
0.380 |
Biomarker
|
disease |
BEFREE |
Applying an endophenotype approach, we investigated a potential impact of the genes of the 5-HT3A and 5-HT3B subunits as well as the novel 5-HT3C, 5-HT3D, and 5-HT3E subunits on CPT performance in subjects with schizophrenia.
|
20356718 |
2010 |
Schizophrenia
|
0.380 |
Biomarker
|
disease |
PSYGENET |
Applying an endophenotype approach, we investigated a potential impact of the genes of the 5-HT3A and 5-HT3B subunits as well as the novel 5-HT3C, 5-HT3D, and 5-HT3E subunits on CPT performance in subjects with schizophrenia.
|
20356718 |
2010 |
Schizophrenia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Taken together, our results suggest that variants in the HTR3A receptor gene can play a role in the treatment outcome of clozapine in schizophrenia patients that are refractory or intolerant of typical antipsychotic therapy.
|
20168265 |
2010 |
Schizophrenia
|
0.380 |
Biomarker
|
disease |
BEFREE |
Few studies have, however, focused on the association between the therapeutic responses to atypical antipsychotics, such as risperidone, and polymorphisms of the 5-HT3 receptor, the only ionotropic ligand-gated serotonin receptor, even though there have been some genetic clues linking HTR3A and schizophrenia.
|
18622264 |
2008 |
Schizophrenia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
To determine the haplotype block structure in the genomic regions of HTR3A and HTR3B, and to examine whether genetic variations in the region show evidence of association with schizophrenia and affective disorder in the Japanese, we performed haplotype-based case-control analysis using 29 polymorphisms.
|
16487942 |
2006 |
Schizophrenia
|
0.380 |
Biomarker
|
disease |
BEFREE |
Further studies are needed to support the hypothesis that HTR3A may contribute to the schizophrenia in these patients.
|
11207027 |
2001 |
Mental Depression
|
0.350 |
Biomarker
|
disease |
BEFREE |
Altogether, our findings suggest a novel 5HT3R-IGF1 mechanism that is distinct from fluoxetine-induced responses and that provides a new therapeutic target for depression, especially bringing significant benefits for SSRI-resistant depressed patients.
|
28439104 |
2018 |
Depressive disorder
|
0.350 |
Biomarker
|
disease |
BEFREE |
Altogether, our findings suggest a novel 5HT3R-IGF1 mechanism that is distinct from fluoxetine-induced responses and that provides a new therapeutic target for depression, especially bringing significant benefits for SSRI-resistant depressed patients.
|
28439104 |
2018 |
Mental Depression
|
0.350 |
Biomarker
|
disease |
BEFREE |
To further explore this hypothesis, we used mice lacking the 5-HT<sub>3</sub> receptor (Htr3a KO) and their wild-type (WT) controls to assess their response in behavioural paradigms relevant to anxiety and depression.
|
28493335 |
2017 |
Depressive disorder
|
0.350 |
Biomarker
|
disease |
BEFREE |
To further explore this hypothesis, we used mice lacking the 5-HT<sub>3</sub> receptor (Htr3a KO) and their wild-type (WT) controls to assess their response in behavioural paradigms relevant to anxiety and depression.
|
28493335 |
2017 |
Mental Depression
|
0.350 |
Biomarker
|
disease |
PSYGENET |
Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response.
|
21937687 |
2012 |
Depressive disorder
|
0.350 |
Biomarker
|
disease |
PSYGENET |
Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response.
|
21937687 |
2012 |
Mental Depression
|
0.350 |
Biomarker
|
disease |
PSYGENET |
Interestingly, a functional polymorphism in HTR3A, encoding the 5-HT3 receptor A subunit, has been reported to be associated with depression and anxiety related traits.
|
22014438 |
2011 |
Mental Depression
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, a functional polymorphism in HTR3A, encoding the 5-HT3 receptor A subunit, has been reported to be associated with depression and anxiety related traits.
|
22014438 |
2011 |
Depressive disorder
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, a functional polymorphism in HTR3A, encoding the 5-HT3 receptor A subunit, has been reported to be associated with depression and anxiety related traits.
|
22014438 |
2011 |
Depressive disorder
|
0.350 |
Biomarker
|
disease |
PSYGENET |
Interestingly, a functional polymorphism in HTR3A, encoding the 5-HT3 receptor A subunit, has been reported to be associated with depression and anxiety related traits.
|
22014438 |
2011 |
Mental Depression
|
0.350 |
Biomarker
|
disease |
PSYGENET |
Impact of the HTR3A gene with early life trauma on emotional brain networks and depressed mood.
|
20694966 |
2010 |
Mental Depression
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
We examined how genetic (brain-derived neurotrophic factor [BDNF] valine 66 to methionine [Val66Met] and serotonin receptor gene 3A [HTR3A]) and early life stress susceptibility factors interact in predicting electroencephalogram (EEG) asymmetry, emotion-elicited heart rate, and self-reported negativity bias, each correlates of risk for depression.
|
20728877 |
2010 |
Mental Depression
|
0.350 |
Biomarker
|
disease |
PSYGENET |
We examined how genetic (brain-derived neurotrophic factor [BDNF] valine 66 to methionine [Val66Met] and serotonin receptor gene 3A [HTR3A]) and early life stress susceptibility factors interact in predicting electroencephalogram (EEG) asymmetry, emotion-elicited heart rate, and self-reported negativity bias, each correlates of risk for depression.
|
20728877 |
2010 |
Depressive disorder
|
0.350 |
Biomarker
|
disease |
PSYGENET |
We examined how genetic (brain-derived neurotrophic factor [BDNF] valine 66 to methionine [Val66Met] and serotonin receptor gene 3A [HTR3A]) and early life stress susceptibility factors interact in predicting electroencephalogram (EEG) asymmetry, emotion-elicited heart rate, and self-reported negativity bias, each correlates of risk for depression.
|
20728877 |
2010 |
Depressive disorder
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
We examined how genetic (brain-derived neurotrophic factor [BDNF] valine 66 to methionine [Val66Met] and serotonin receptor gene 3A [HTR3A]) and early life stress susceptibility factors interact in predicting electroencephalogram (EEG) asymmetry, emotion-elicited heart rate, and self-reported negativity bias, each correlates of risk for depression.
|
20728877 |
2010 |