|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between the apolipoprotein B gene 3' hypervariable region alleles and coronary artery disease in Finnish patients with angiographically documented coronary artery disease.
|
1732399 |
1992 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Familial hypercholesterolemia (FH), characterized by isolated elevation of plasmatic low-density lipoprotein (LDL) cholesterol and premature coronary heart disease (CHD), is associated with mutations in three major genes: LDL receptor (LDLR), apolipoprotein B (APOB) and proprotein convertase subtilisin/kexin 9 (PCSK9).
|
22244043 |
2012 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Cox proportional analysis estimated ApoB-related risk of incident CHD over a median follow-up period of 12.5 years with adjustments for nonlipid CHD risk factors.
|
29370999 |
2019 |
|
Coronary heart disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
These results, that associate overexpression of fibrinogen with enhance apolipoprotein B secretion, may be significant since epidemiological studies indicate that elevated levels of fibrinogen and lipids are independent risk factors in coronary artery disease.
|
10873614 |
2000 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Three polymorphic sites of the apolipoprotein B gene - the insertion/deletion signal peptide, XbaI and EcoRI sites - were examined in a sample of 107 healthy men and in 46 men with evidence of coronary heart disease selected from a large population survey of South Asians aged 40-69 in London, U.K.
|
1789809 |
1991 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
SORT1 rs599839 was associated with CHD risk (OR 1.20; 1.15-1.26) as well as total- and LDL-cholesterol, and apolipoprotein B. ANGPTL3 rs12042319 was associated with CHD risk (OR 1.11; 1.03, 1.19), total- and LDL-cholesterol, triglycerides, and interleukin-6.
|
21804106 |
2012 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Four gene variants related to lipid metabolism (including the rs562338 and rs503662 variants of the APOB gene, the rs7767084 variant of the LPA gene and the rs2246942 variant of the LIPA gene) have been shown to be associated with coronary heart disease (CHD).
|
23653095 |
2013 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Association between apolipoprotein B EcoRI polymorphisms and coronary heart disease : A meta-analysis.
|
27637205 |
2016 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Elevated plasma levels of apolipoprotein B (apoB)-containing lipoproteins constitute a major risk factor for the development of coronary heart disease.
|
8533758 |
1995 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Together these results suggest that inherited variations of the apolipoprotein-B gene, probably in the form of charged aminoacid substitutions, influence circulating cholesterol concentration, and that these and other functional variants of the apolipoprotein-B gene affect susceptibility to coronary heart disease and obesity.
|
2904569 |
1989 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ApoA-I levels were associated with higher levels of CHD risk factors: higher body mass index, HbA1c, non-HDL-C, triglycerides, apolipoprotein B, systolic blood pressure, and C-reactive protein, within fixed HDL-C quartiles.
|
28775061 |
2017 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A high-resolution method was used to study the allele frequencies of a hypervariable minisatellite region close to the apolipoprotein B gene in 110 patients with severe coronary disease and in 117 normal controls.
|
2351870 |
1990 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association of the apolipoprotein B gene polymorphisms with cholesterol levels and response to fluvastatin in Brazilian individuals with high risk for coronary heart disease.
|
11071065 |
2000 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Effect of SORT1, APOB and APOE polymorphisms on LDL-C and coronary heart disease in Pakistani subjects and their comparison with Northwick Park Heart Study II.
|
27112212 |
2016 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To determine whether the APOE association may be a risk factor for coronary disease as well, we examined two APOB gene restriction sites that have previously been found to be associated with coronary artery disease, especially myocardial infarctions.
|
8530010 |
1995 |
|
Coronary heart disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We aimed to investigate the cumulative effect of high CRP level and apolipoprotein B-to-apolipoprotein A-1 (ApoB/ApoA-1) ratio on the incidence of ischemic stroke (IS) or coronary heart disease (CHD) in a Mongolian population in China.
|
27554116 |
2016 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
LHGDN |
Monounsaturated fatty acyl-coenzyme A is predictive of atherosclerosis in human apoB-100 transgenic, LDLr-/- mice.
|
17277381 |
2007 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In external validation analyses, a genetic score consisting of variants with naturally occurring discordance between levels of LDL-C and apoB was associated with a similar risk of CHD per unit change in apoB level (OR, 0.782 [95% CI, 0.720-0.845] vs 0.793 [95% CI, 0.774-0.812]; P = .79 for difference), but a significantly attenuated risk of CHD per unit change in LDL-C level (OR, 0.916 [95% CI, 0.890-0.943] vs 0.831 [95% CI, 0.816-0.847]; P < .001) compared with a genetic score associated with concordant changes in levels of LDL-C and apoB.
|
28846118 |
2017 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Autosomal dominant hypercholesterolemia (ADH; OMIM144400), a risk factor for coronary heart disease, is characterized by an increase in low-density lipoprotein cholesterol levels that is associated with mutations in the genes LDLR (encoding low-density lipoprotein receptor) or APOB (encoding apolipoprotein B).
|
12730697 |
2003 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis indicated that ApoB XbaI allele confers a significant risk towards the development of CHD among the Han Chinese population.
|
27172140 |
2016 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Recent evidence indicates that PCSK9 also modulates the metabolism of triglyceride-rich apolipoprotein B (apoB) lipoproteins, another important coronary heart disease risk factor.
|
25070550 |
2014 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for age, sex, smoking and systolic blood pressure, compared to those with no detectable mutation, the odds ratio of having CHD in those with an LDLR mutation was 1.84 (95% CI 1.10 to 3.06), for APOB 3.40 (0.71 to 16.36), and for PCSK9 19.96 (1.88 to 211.5; p = 0.001 overall).
|
17142622 |
2006 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein B correlates with intra-plaque necrotic core volume in stable coronary artery disease.
|
30779793 |
2019 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Studies comparing patients and controls, however, did not confirm previous studies suggesting that the multi-allelic variation at the 3'VNTR region of the apolipoprotein B gene was associated with coronary artery disease.
|
1418918 |
1992 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
None of the 274 individuals in the coronary heart disease (CHD) groups was found to be a carrier of the apoB allele Arg3500----Gln, previously shown to be associated with an apoB protein defective in binding to the low density lipoprotein receptor (LDL-R).
|
1346774 |
1992 |