|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
None of the 274 individuals in the coronary heart disease (CHD) groups was found to be a carrier of the apoB allele Arg3500----Gln, previously shown to be associated with an apoB protein defective in binding to the low density lipoprotein receptor (LDL-R).
|
1346774 |
1992 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Lipid parameters and apolipoprotein B RFLP studies: comparison of normal and coronary heart disease groups as defined by angiography.
|
1362695 |
1992 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Studies comparing patients and controls, however, did not confirm previous studies suggesting that the multi-allelic variation at the 3'VNTR region of the apolipoprotein B gene was associated with coronary artery disease.
|
1418918 |
1992 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We have investigated the frequency of Hind III DNA polymorphism of the human apolipoprotein B gene in a Canadian Caucasian population with coronary artery disease, as documented by angiography, and a healthy control population.
|
1477972 |
1992 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between the apolipoprotein B gene 3' hypervariable region alleles and coronary artery disease in Finnish patients with angiographically documented coronary artery disease.
|
1732399 |
1992 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Three polymorphic sites of the apolipoprotein B gene - the insertion/deletion signal peptide, XbaI and EcoRI sites - were examined in a sample of 107 healthy men and in 46 men with evidence of coronary heart disease selected from a large population survey of South Asians aged 40-69 in London, U.K.
|
1789809 |
1991 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association of DNA polymorphism at the apolipoprotein B gene locus with coronary heart disease and serum very low density lipoprotein levels.
|
1967524 |
1990 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
In conclusion, (1) the presence of NIDDM in the proband appears to be associated in siblings with more profound lipid and lipoprotein changes (especially low HDL cholesterol and high total triglycerides) than a history of CHD in the proband, (2) a history of CHD in the proband is associated in children with apolipoprotein changes favouring atherosclerosis (low apolipoprotein A1, high apolipoprotein B, low apolipoprotein A1/B ratio).
|
2064632 |
1991 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A high-resolution method was used to study the allele frequencies of a hypervariable minisatellite region close to the apolipoprotein B gene in 110 patients with severe coronary disease and in 117 normal controls.
|
2351870 |
1990 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein B allotypes MB19(1) and MB19(2) in subjects with coronary artery disease and hypercholesterolemia.
|
2434069 |
1987 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Together these results suggest that inherited variations of the apolipoprotein-B gene, probably in the form of charged aminoacid substitutions, influence circulating cholesterol concentration, and that these and other functional variants of the apolipoprotein-B gene affect susceptibility to coronary heart disease and obesity.
|
2904569 |
1989 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Immunologically defined alleles of the pig apolipoprotein B (ApoB) locus (apoB) are correlated with different blood cholesterol levels and predisposition towards premature coronary heart disease.
|
2905687 |
1988 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Variation in the concentrations of both plasma and low density lipoprotein cholesterol, as well as apolipoprotein B, were related neither to age at death from CHD nor to the clinical course of CHD.
|
2923577 |
1989 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Coronary heart disease risk correlates directly with plasma concentrations of lipoprotein(a) (Lp(a)), a low-density lipoprotein-like particle distinguished by the presence of the glycoprotein apolipoprotein(a) (apo(a)), which is bound to apolipoprotein B-100 (apoB-100) by disulfide bridges.
|
2976021 |
1988 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Levels of apolipoprotein B, the protein component of low-density lipoproteins, correlate with the risk of coronary heart disease.
|
3024002 |
1986 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein B and apolipoprotein AI as predictors of coronary artery disease.
|
3141025 |
1988 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The weak association of EcoRI, Xbal, and Mspl polymorphisms of the apoB gene with CHD indicates that the three RFLPs cannot be used as a predictor for the risk of CHD in the Chinese population.
|
7533671 |
1995 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Therefore, it was suggested that genetic variation at XbaI site of apoB gene might contribute to the determination of plasma HDL-C level and development of CHD in people among Chinese Han nationality.
|
7910546 |
1994 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Low density lipoprotein cholesterol/apolipoprotein B-100 ratio: interaction of family history of premature atherosclerotic coronary artery disease with race and gender in 7 to 11 year olds.
|
7936858 |
1994 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The presence of mutant apo B-100 in low-density lipoproteins (LDL) markedly reduces their affinity for the LDL receptor, leading to hypercholesterolaemia and increased proneness to coronary artery disease.
|
8141833 |
1993 |
|
Coronary heart disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Apolipoprotein B levels were strongly associated with coronary artery disease in four of five prospective studies but were more predictive of coronary artery disease than were total cholesterol levels in only two of the four studies.
|
8185133 |
1994 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
By direct comparison of the Lp(a) and apoB plasma concentrations in 28 affected and 31 unaffected members of seven families carrying the FH trait and without history of coronary artery disease, we reached the conclusion that LDL receptor activity is not a major determinant of the Lp(a) plasma levels in these subjects.
|
8187228 |
1994 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
An elevated plasma level of apolipoprotein B (apoB), the major protein of low density lipoproteins, is a risk factor for coronary artery disease.
|
8349099 |
1993 |
|
Coronary heart disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
An investigation of the influence of selected factors on the clinical expression of the FH Afrikaner-1 mutation in this family indicated that it was especially the elevated apolipoprotein (a) levels, in addition to low levels of high density lipoprotein cholesterol and raised triglyceride and apolipoprotein B levels, that were associated with a greater risk of developing CHD.
|
8370148 |
1993 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Using the CE technique, the apoB VNTR loci from some individuals in genotyping were examined towards precise DNA diagnosis for coronary heart disease.
|
8529610 |
1995 |