APOB, apolipoprotein B, 338

N. diseases: 339; N. variants: 122
Disease: beta^0^ Thalassemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0271980
Disease: beta^0^ Thalassemia
beta^0^ Thalassemia 		0.010 AlteredExpression disease BEFREE The LDL-lowering effect of beta(0)-thalassemia may be related to (1) the mild erythroid hyperplasia, which would increase the LDL removal by the bone marrow, and (2) the chronic activation of the monocyte-macrophage system, causing an increased secretion of some cytokines (interleukin-1, interleukin-6, and tumor necrosis factor-alpha) known to affect the hepatic secretion and the receptor-mediated removal of apolipoprotein B-containing lipoproteins. 10634824 2000