|
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this study, our aim was to investigate the role of fetuin-A in relation with pro-inflammatory cytokines (IL-6, IL-18), adipokines (adiponectin, leptin), chemokine (MCP-1), and adhesion molecules (ICAM-1, VCAM-1) in control and DKD subjects.
|
30632070 |
2019 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
No significant association was detected between ICAM1 rs5498 and DN susceptibility in allelic and recessive models (p > 0.05).
|
30587209 |
2018 |
|
Diabetic Nephropathy
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The presence of DN involved a lower leukocyte rolling velocity and an increased rolling flux and adhesion. miR-31 levels were positively correlated with leukocyte rolling velocity and negatively associated to leukocyte adhesion, TNFα, IL-6 and ICAM-1 levels.
|
30355913 |
2018 |
|
Diabetic Nephropathy
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In view of the regulation of inflammation and fibrosis by myocardin-related transcription factor A (MRTF-A), we are highly concerned whether CK2α promotes AGEs-induced expressions of FN and ICAM-1 in glomerular mesangial cells via activation of MRTF-A, thus affecting the pathogenesis of DN.
|
29223351 |
2018 |
|
Diabetic Nephropathy
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Both QUE and QUE nanoparticle complex preconditioning ameliorated the pathological damage of kidney and improved renal function, alleviated renal oxidative stress injury, restricted inflammatory cells infiltration, and downregulated the ICAM-1 expression as compared to DN group, while QUE nanoparticle complex significantly alleviated this effect.
|
29123394 |
2017 |
|
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
BEFREE |
These data suggest that emodin protects against DN and that the underlying mechanism may involve the suppression of inflammation, ICAM-1 and Bax, and activation of the PI3K/Akt/GSK-3β pathway.
|
29201232 |
2017 |
|
Diabetic Nephropathy
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, plasma ICAM-1 levels were increased from NGT subjects to T2D patients without and with DN (P<0.001).
|
26255081 |
2016 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A number of studies evaluated the association of intracellular adhesion molecule-1 (ICAM-1) K469E (rs5498, A/G) gene polymorphism with diabetic microvascular complications (DMI) including diabetic nephropathy (DN) and diabetic retinopathy (DR) in different populations.
|
23922864 |
2013 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
Evaluation of the association between the common E469K polymorphism in the ICAM-1 gene and diabetic nephropathy among type 1 diabetic patients in GoKinD population.
|
18505543 |
2008 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Evaluation of the association between the common E469K polymorphism in the ICAM-1 gene and diabetic nephropathy among type 1 diabetic patients in GoKinD population.
|
18505543 |
2008 |
|
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
RGD |
Renoprotective effect of rosiglitazone through the suppression of renal intercellular adhesion molecule-1 expression in streptozotocin-induced diabetic rats.
|
19246972 |
2008 |
|
Diabetic Nephropathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The present study provided evidence that SNPs rs281432(C/G) and rs5498 E469K(A/G) in the ICAM-1 gene confer susceptibility to the development of T1D and might also be associated with diabetic nephropathy in Swedish Caucasians.
|
16978373 |
2006 |