|
Diabetic Retinopathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The results of this current meta-analysis indicated that the increased level of ICAM-1 generally exists in the patients with DR and it may associated with the severity of DR.
|
31109934 |
2019 |
|
Diabetic Retinopathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
The downstream exacerbating factors including vascular endothelial growth factor (VEGF), intercellular adhesion molecule 1 (ICAM-1) and matrix metalloproteinase 2 (MMP2), which are implicated in the pathogenesis of DR and closely related to oxidative stress were also analyzed.
|
30662833 |
2019 |
|
Diabetic Retinopathy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between diabetic retinopathy in type 2 diabetes and the ICAM-1 rs5498 polymorphism: a meta-analysis of case-control studies.
|
30419874 |
2018 |
|
Diabetic Retinopathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, treatment with Niaspan significantly improved clinical and histopathological outcomes; decreased the expression levels of TNF‑α, NF‑κB, iNOS and ICAM‑1; and decreased apoptosis and BRB breakdown, as compared with in the retinas of DR rats.
|
28138697 |
2017 |
|
Diabetic Retinopathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Intracellular adhesion molecule 1 (ICAM-1) is an important inflammatory factor that causes retinal damage during diabetic retinopathy.
|
28104396 |
2017 |
|
Diabetic Retinopathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Inhibition or knock down of endothelial 12/15-LO in HRECs blocked HG-induced expression of ICAM-1, a well-known identified important molecule for leukocyte adhesion in DR.
|
28351645 |
2017 |
|
Diabetic Retinopathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The data indicated that TUDCA could ameliorate DR by decreasing NO content and down-regulating the protein expression of ICAM-1, NOS, NF-κB p65 and VEGF.
|
26988565 |
2016 |
|
Diabetic Retinopathy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results revealed that SNP rs5498 in ICAM-1 gene and IVS5-13insC variant in HMGA1 gene were not associated with the susceptibility of DR in the Chinese T2DM cohort.
|
26717491 |
2016 |
|
Diabetic Retinopathy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between the ICAM-1 K469E polymorphism and diabetic retinopathy in Type 2 diabetes mellitus: a meta-analysis.
|
24612665 |
2014 |
|
Diabetic Retinopathy
|
0.600 |
Therapeutic
|
disease |
RGD |
Silybin reduces obliterated retinal capillaries in experimental diabetic retinopathy in rats.
|
25066112 |
2014 |
|
Diabetic Retinopathy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in ICAM1, PPARGC1A and MTHFR are potentially associated with different phenotypes of diabetic retinopathy.
|
25324196 |
2014 |
|
Diabetic Retinopathy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A number of studies evaluated the association of intracellular adhesion molecule-1 (ICAM-1) K469E (rs5498, A/G) gene polymorphism with diabetic microvascular complications (DMI) including diabetic nephropathy (DN) and diabetic retinopathy (DR) in different populations.
|
23922864 |
2013 |
|
Diabetic Retinopathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in NOS3, VEGF, ITGA2, and ICAM1 are also associated with diabetic retinopathy after meta-analysis.
|
19587357 |
2009 |
|
Diabetic Retinopathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Furthermore, ICAM-1 has been demonstrated to be involved in leukocyte-mediated endothelial injury in diabetic retinopathy.
|
19482023 |
2009 |
|
Diabetic Retinopathy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A significantly higher frequency of the EE genotype of the K469E polymorphism of the ICAM-1 was found in the patients with PDR compared with those without diabetic retinopathy (OR = 2.0, 95% confidence interval [CI] = 1.1-3.5; P = 0.013), whereas the G241A polymorphism of the ICAM-1 gene failed to yield an association with PDR.
|
18942221 |
2008 |
|
Diabetic Retinopathy
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
A significantly higher frequency of the EE genotype of the K469E polymorphism of the ICAM-1 was found in the patients with PDR compared with those without diabetic retinopathy (OR = 2.0, 95% confidence interval [CI] = 1.1-3.5; P = 0.013), whereas the G241A polymorphism of the ICAM-1 gene failed to yield an association with PDR.
|
18942221 |
2008 |
|
Diabetic Retinopathy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The ICAM-1 gene K469E polymorphism is associated with diabetic retinopathy in Chinese patients with Type 2 diabetes.
|
16759306 |
2006 |
|
Diabetic Retinopathy
|
0.600 |
Biomarker
|
disease |
LHGDN |
Soluble adhesion molecules are not involved in the development of retinopathy in type 2 diabetic patients.
|
15666579 |
2004 |
|
Diabetic Retinopathy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The frequency of ICAM-1 469KK genotype and K allele were significantly higher in the patients with diabetic retinopathy than in those without retinopathy (genotype 42% vs. 20%, chi2 = 6.70, P = 0.035; allele 66% vs. 50%, chi2 = 6.49, P = 0.011).
|
12027924 |
2002 |
|
Diabetic Retinopathy
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
The frequency of ICAM-1 469KK genotype and K allele were significantly higher in the patients with diabetic retinopathy than in those without retinopathy (genotype 42% vs. 20%, chi2 = 6.70, P = 0.035; allele 66% vs. 50%, chi2 = 6.49, P = 0.011).
|
12027924 |
2002 |
|
Diabetic Retinopathy
|
0.600 |
Therapeutic
|
disease |
CTD_human |
These data identify the causal role of leukocytes in the pathogenesis of diabetic retinopathy and establish the potential utility of ICAM-1 inhibition as a therapeutic strategy for the prevention of diabetic retinopathy.
|
10485912 |
1999 |