|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
PubMed, Scopus, Embase, ProQuest and Google Scholar databases were searched to fined interventional studies from the effects of chromium on inflammatory biomarkers such as tumour necrosis factor a (TNF-a), C-reactive protein (CRP), interleukins, monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1) and adipocytokines in hyperglycaemia and diabetes.
|
31330062 |
2019 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
In vitro studies demonstrated dapagliflozin-mediated attenuation of tumour necrosis factor α- and hyperglycaemia-induced increases in intercellular adhesion molecule-1, vascular cell adhesion molecule-1, plasminogen activator inhibitor type 1 and NFκB expression.
|
28976221 |
2018 |
|
Hyperglycemia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Egr-1 downstream gene targets, tissue factor (TF) and intercellular adhesion molecule-1 (ICAM-1) expression were increased in hRECs which was reduced by Egr-1 silencing in hyperglycemia.
|
29307595 |
2018 |
|
Hyperglycemia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Hyperglycemia increased the mRNA expression and protein levels of malondialdehyde (MDA), superoxide dismutase (SOD), monocyte chemoattractant protein‑1 (MCP‑1), intercellular adhesion molecule‑1 (ICAM‑1), fibronectin (FN), collagenase type 1 (COL‑1), HMGB1, RAGE and NF‑κB, and the effects could be reversed by dapagliflozin in a concentration‑dependent manner.
|
30132524 |
2018 |
|
Hyperglycemia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Here, we studied the effects of acute hyperglycemia on in vivo intercellular adhesion molecule-1 (ICAM-1) expression, neutrophil recruitment, and brain damage after ischemia/reperfusion in mice and tested whether the natural antioxidant uric acid was protective.Hyperglycemia was induced by i.p. administration of dextrose 45 min before transient occlusion of the middle cerebral artery.
|
27981484 |
2017 |
|
Hyperglycemia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Our data support that endothelial, rather than monocytic/macrophagic, 12/15-LO has a critical role in hyperglycemia-induced ICAM-1 expression, leukocyte adhesion, and subsequent local retinal barrier dysfunction.
|
28351645 |
2017 |
|
Hyperglycemia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These results proved that the up-regulation of ICAM-1 with hyperglycaemia is mediated by O-GlcNAc modification of Sp1.
|
28104396 |
2017 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
RGD |
Our results showed that long term hyperglycemia in diabetic rats caused the degeneration of neurons and the up-regulation of serum AGEs, and also the up-regulation of RAGE, NF-kappaB p65, VCAM-1 and ICAM-1 in the brain.
|
20495289 |
2010 |
|
Hyperglycemia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study was to evaluate the enhanced effect of hyperglycemia and the attenuating effect of siRNAs on ICAM-1 expression in cultured endothelial cells.
|
18365231 |
2008 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Chronic treatment with AVE3085 did not alter arterial BP or severe hyperglycaemia, but did lead to significantly increased production of eNOS (+95%), cGMP (+128%) and VASP phosphorylation (+65%) as well as to improved vascular function (+36%) associated with reduced production of ICAM-1 (-36%) and VCAM-1 (-58%).
|
18825362 |
2008 |
|
Hyperglycemia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Thus, ICAM-1 expression may share common genetic modulation with traits related to obesity, insulin resistance, and HDL3 cholesterol, but not with hyperglycemia or hypertension per se.
|
15448102 |
2004 |