ICAM1, intercellular adhesion molecule 1, 3383

N. diseases: 737; N. variants: 18
Disease: Thyroid cancer metastatic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1096666
Disease: Thyroid cancer metastatic
Thyroid cancer metastatic 		0.010 Biomarker disease BEFREE Patient-derived ATC cells overexpressed ICAM-1 and were largely eliminated by autologous ICAM-1 CAR T cells <i>in vitro</i> and in animal models.<b>Conclusions:</b> Our findings are the first demonstration of CAR T therapy against both a metastatic, thyroid cancer cell line and advanced ATC patient-derived tumors that exhibit dramatic therapeutic efficacy and survival benefit in animal studies.<i></i>. 29025766 2017