|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the effects of GPR120 activation on dietary fat intake or obesity are not clearly understood.
|
31806728 |
2020 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The combination of physical exercise and ω3 food sources could provide a new strategy against obesity through the modulation of hepatic GPR120 and an increase in exercise performance.
|
30771734 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings indicate that GPR120 activation is protective against lipotoxicity-induced pancreatic β-cell dysfunction, via the mediation of PDX1 expression and inhibition of islet inflammation, and that GPR120 activation may serve as a preventative and therapeutic target for obesity and diabetes.
|
30523046 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, these data suggest that activation of brown adipocytes with the GPR120 agonist TUG-891 is a promising strategy to increase lipid combustion and reduce obesity.
|
29343498 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insulinotropic effects of GPR120 agonists are altered in obese diabetic and obese non-diabetic states.
|
27980130 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Obesity is associated with altered duodenal expression of FFAR1, FFAR4 and CD36, suggesting altered capacity for the sensing, absorption and metabolism, of dietary lipids.
|
27811952 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The effects of FAs on TNF-α, IL-6, IL-10 and adiponectin expression in non-obese and MO subjects were significantly annulled when the GPR120 gene was silenced in visceral adipocytes differentiated from human mesenchymal stem cells.
|
27299582 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we evaluate the expression and potential role of hypothalamic GPR120 and GPR40 as targets for the treatment of obesity.
|
28446241 |
2017 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In humans, the loss of function p.R270H variant of the gene FFAR4 has been associated with a lower protein activity, an increased risk of obesity and higher fasting plasma glucose levels.
|
27212621 |
2016 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
p.R270H (rs116454156) in the long chain fatty acid 7TM receptor FFAR4 (GPR120) which results in impaired Gαq (Gq) coupled signalling, has been associated with obesity.
|
27068006 |
2016 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gpr120-deficient mice develop obesity and both impaired fasting glucose and glucose intolerance under a high-fat diet.
|
26025001 |
2015 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
G protein-coupled receptor 120 (GPR 120) levels are reduced in pediatric OSA and obesity (particularly when both are present) and may play a role in modulating the degree of insulin resistance.
|
24790272 |
2014 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Stratifying the patients with the GPR120 270H variant on the basis of their PNPLA3 polymorphism, we demonstrated a significant interaction effect on ALT levels (P = 0.00001), suggesting a driving effect of the PNPLA3 148M allele on liver injury in children with obesity carrying this variant.
|
25250621 |
2014 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
We analyzed the association between GPR120 and obesity, and the FA effects on its expression.
|
24913719 |
2014 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, GPR120, the sensing receptor for long-chain free fatty acids, represents a novel drug target for the treatment of obesity and diabetes.
|
23317787 |
2013 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we show that GPR120-deficient mice fed a high-fat diet develop obesity, glucose intolerance and fatty liver with decreased adipocyte differentiation and lipogenesis and enhanced hepatic lipogenesis.
|
22343897 |
2012 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, GPR120 KO mice develop obesity, increased inflammation, and insulin resistance, consistent with a role for GPR120 signaling in the metabolic syndrome and diabetes mellitus.
|
22560206 |
2012 |