|
Absence of sensation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
A role has been suggested for the two-pore domain (K2P) potassium channel, TWIK-related spinal cord potassium channel (TRESK, encoded by KCNK18), in pain pathways and general anaesthesia.
|
20871611 |
2010 |
|
Cancer Pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Here, we found that the reduced abundance of potassium channels called TRESK in dorsal root ganglion (DRG) neurons sensitized nociceptive sensory neurons and cancer-associated pain.
|
30327410 |
2018 |
|
Common Migraine
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Our study shows the presence of several KCNK18 gene mutations in both migraine with aura and migraine without aura.
|
25324165 |
2014 |
|
Common Migraine
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Sixty patients with migraine without aura (MO) or with different types of migraine with aura (MA), including sporadic hemiplegic, familial hemiplegic, and probable familial hemiplegic, were screened for mutations in the four genes previously linked with different types of migraine (ATP1A2, CACNA1A, SCN1A, and KCNK18).
|
26747084 |
2016 |
|
Familial (FPAH)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Sixty patients with migraine without aura (MO) or with different types of migraine with aura (MA), including sporadic hemiplegic, familial hemiplegic, and probable familial hemiplegic, were screened for mutations in the four genes previously linked with different types of migraine (ATP1A2, CACNA1A, SCN1A, and KCNK18).
|
26747084 |
2016 |
|
Familial migraine
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Other genes displayed enriched expression in the trigeminal compared to dorsal root ganglion, and in-depth transcriptomic analysis of the KCNK18 gene underlying familial migraine shows selective neural expression within two specific populations of ganglionic neurons.
|
28699403 |
2018 |
|
Familial migraine
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura.
|
20871611 |
2010 |
|
Hemiplegic migraine, familial type 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
On the other hand, the presence of KCNK18 mutation indicated another FHM subtype.
|
26747084 |
2016 |
|
Hyperalgesia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Compared with SNI rats, intrathecal injection of TRESK gene recombinant adenovirus significantly downregulated the expression levels of Cx36 and Cx43 and suppressed the activation of gliocytes in the spinal cord, with hyperalgesia significantly reduced.
|
28160200 |
2017 |
|
Hyperalgesia, Thermal
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Using the chronic nitroglycerine rodent migraine model, we demonstrate that mice lacking TRESK develop exaggerated nitroglycerine-induced mechanical and thermal hyperalgesia, and furthermore, show that cloxyquin conversely is able to prevent sensitization.
|
31742594 |
2019 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Thus, we investigated the expression pattern of three 2-pore domain potassium channels (K2Ps) TASK1, TASK3 and TRESK in advanced oral squamous cell carcinoma (OSCC), the commonest oral malignancy.
|
30818127 |
2019 |
|
Migraine Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
This review will elaborate on the possible role of the TRESK channel in regulating neuronal excitability, its role in migraine pathogenesis, and on promising therapeutic opportunities targeting this channel.
|
21855646 |
2011 |
|
Migraine Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
This review will focus on the genetics of migraine with particular emphasis placed on the potentially important role genes HEPH (responsible for iron transport and homeostasis) and KCNK18 (important for the transport and homeostasis of potassium) play in migraine cause.
|
28389699 |
2017 |
|
Migraine Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, our findings provide evidence for a role of TRESK in migraine pathogenesis and its suitability as a therapeutic target.
|
31742594 |
2019 |
|
Migraine Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Recently, several mutations in KCNK18 have also been found as causative factors in migraine development.
|
26747084 |
2016 |
|
Migraine Disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We also identified prominent TRESK expression in migraine-salient areas such as the trigeminal ganglion.
|
20871611 |
2010 |
|
Migraine Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
This new inhibitor may be of use to probe the role of TRESK channel in migraine and nociception.
|
30979812 |
2019 |
|
Migraine Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
KCNK18 (TRESK) genetic variants in Italian patients with migraine.
|
25324165 |
2014 |
|
Migraine Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In this study, three common polymorphisms in the KCNK18 gene were analysed for genetic variation in an Australian case-control migraine population consisting of 340 migraine cases and 345 controls.
|
23911303 |
2013 |
|
Migraine Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Tandem pore domain weak inward rectifier potassium channel (TWIK)-related spinal cord K⁺ (TRESK; K<sub>2P</sub>18.1) channel is the only member of the two-pore domain K⁺ (K<sub>2P</sub>) channel family that is activated by an increase in intracellular Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>i</sub>) and linked to migraines.
|
29973548 |
2018 |
|
Migraine Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we identify a new mechanism, termed frameshift mutation-induced alternative translation initiation (fsATI), that may explain why only TRESK-MT is associated with migraine. fsATI leads to the production of a second protein fragment, TRESK-MT2, which co-assembles with and inhibits TREK1 and TREK2, two other two-pore-domain K+ channels, to increase trigeminal sensory neuron excitability, leading to a migraine-like phenotype in rodents.
|
30573346 |
2019 |
|
Migraine Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
TWIK-related spinal cord potassium channel is involved in migraine by screening the KCNK18 gene in subjects diagnosed with migraine.
|
23919895 |
2013 |
|
Migraine Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In this issue of Neuron, Royal et al.(2018) find that a mutant form of the TRESK ion channel linked to migraine undergoes alternative translation to produce an inhibitory protein that blocks TREK channels, leading to neuronal hyperexcitability and migraine in rodents.
|
30653930 |
2019 |
|
Migraine Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A single migraine study using a candidate-gene approach was performed in 2010 identifying a rare mutation in the TRESK potassium channel segregating in a large family with migraine with aura, but this finding has later become questioned.
|
28255817 |
2017 |
|
Migraine Disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In situ hybridization studies of the mouse Kcnk18 ortholog show that it is developmentally expressed in the trigeminal and dorsal root ganglia, further supporting the involvement of this gene in migraine pathogenesis.
|
23030542 |
2012 |