Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 13
0.600 SusceptibilityMutation disease CLINVAR
MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 13
0.600 Biomarker disease CTD_human
MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 13
0.600 GeneticVariation disease CLINVAR A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura. 20871611 2010
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.100 AlteredExpression group BEFREE We also identified prominent TRESK expression in migraine-salient areas such as the trigeminal ganglion. 20871611 2010
CUI: C0154723
Disease: Migraine with Aura
Migraine with Aura
0.050 Biomarker disease BEFREE These results therefore support a role for TRESK in the pathogenesis of typical migraine with aura and further support the role of this channel as a potential therapeutic target. 20871611 2010
CUI: C2349453
Disease: Familial migraine
Familial migraine
0.020 GeneticVariation disease BEFREE A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura. 20871611 2010
CUI: C0278134
Disease: Absence of sensation
Absence of sensation
0.010 Biomarker phenotype BEFREE A role has been suggested for the two-pore domain (K2P) potassium channel, TWIK-related spinal cord potassium channel (TRESK, encoded by KCNK18), in pain pathways and general anaesthesia. 20871611 2010
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.100 Biomarker group BEFREE This review will elaborate on the possible role of the TRESK channel in regulating neuronal excitability, its role in migraine pathogenesis, and on promising therapeutic opportunities targeting this channel. 21855646 2011
CUI: C0154723
Disease: Migraine with Aura
Migraine with Aura
0.050 GeneticVariation disease BEFREE Recently, a mutation in the KCNK18 gene, encoding the TRESK two-pore domain potassium channel, was described in a large family with migraine with aura. 21855646 2011
CUI: C0030193
Disease: Pain
Pain
0.040 Biomarker phenotype BEFREE Additional evidence of a biological role of TRESK channels was provided by behavioral evidence of pain (flinching and licking), in vivo electrophysiological evidence of C-nociceptor activation following IBA injection in the rat hindpaw, and increased sensitivity to painful pressure after TRESK knockdown in vivo. 21527011 2011
MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 13
0.600 Biomarker disease GENOMICS_ENGLAND Functional analysis of missense variants in the TRESK (KCNK18) K channel. 22355750 2012
MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 13
0.600 Biomarker disease GENOMICS_ENGLAND Functional analysis of missense variants in the TRESK (KCNK18) K channel. 22355750 2012
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.100 AlteredExpression group BEFREE In situ hybridization studies of the mouse Kcnk18 ortholog show that it is developmentally expressed in the trigeminal and dorsal root ganglia, further supporting the involvement of this gene in migraine pathogenesis. 23030542 2012
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.100 GeneticVariation group BEFREE In this study, three common polymorphisms in the KCNK18 gene were analysed for genetic variation in an Australian case-control migraine population consisting of 340 migraine cases and 345 controls. 23911303 2013
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.100 Biomarker group BEFREE TWIK-related spinal cord potassium channel is involved in migraine by screening the KCNK18 gene in subjects diagnosed with migraine. 23919895 2013
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.100 GeneticVariation group BEFREE KCNK18 (TRESK) genetic variants in Italian patients with migraine. 25324165 2014
CUI: C0154723
Disease: Migraine with Aura
Migraine with Aura
0.050 GeneticVariation disease BEFREE Our study shows the presence of several KCNK18 gene mutations in both migraine with aura and migraine without aura. 25324165 2014
CUI: C0338480
Disease: Common Migraine
Common Migraine
0.020 GeneticVariation disease BEFREE Our study shows the presence of several KCNK18 gene mutations in both migraine with aura and migraine without aura. 25324165 2014
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.100 GeneticVariation group BEFREE Recently, several mutations in KCNK18 have also been found as causative factors in migraine development. 26747084 2016
CUI: C0154723
Disease: Migraine with Aura
Migraine with Aura
0.050 GeneticVariation disease BEFREE The second, already known missense mutation S231P in KCNK18 was found in a female MA patient. 26747084 2016
CUI: C0030193
Disease: Pain
Pain
0.040 Biomarker phenotype BEFREE We investigated the action of AristA on TREK and TRESK, potassium (K2P) channels, which are potential therapeutic targets in pain. 26914156 2016
CUI: C0338480
Disease: Common Migraine
Common Migraine
0.020 GeneticVariation disease BEFREE Sixty patients with migraine without aura (MO) or with different types of migraine with aura (MA), including sporadic hemiplegic, familial hemiplegic, and probable familial hemiplegic, were screened for mutations in the four genes previously linked with different types of migraine (ATP1A2, CACNA1A, SCN1A, and KCNK18). 26747084 2016
CUI: C1611743
Disease: Familial (FPAH)
Familial (FPAH)
0.010 GeneticVariation disease BEFREE Sixty patients with migraine without aura (MO) or with different types of migraine with aura (MA), including sporadic hemiplegic, familial hemiplegic, and probable familial hemiplegic, were screened for mutations in the four genes previously linked with different types of migraine (ATP1A2, CACNA1A, SCN1A, and KCNK18). 26747084 2016
Hemiplegic migraine, familial type 1
0.010 GeneticVariation disease BEFREE On the other hand, the presence of KCNK18 mutation indicated another FHM subtype. 26747084 2016
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders
0.100 Biomarker group BEFREE This review will focus on the genetics of migraine with particular emphasis placed on the potentially important role genes HEPH (responsible for iron transport and homeostasis) and KCNK18 (important for the transport and homeostasis of potassium) play in migraine cause. 28389699 2017