IRF8, interferon regulatory factor 8, 3394

N. diseases: 149; N. variants: 20
Disease: Systemic Scleroderma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.020 GeneticVariation disease BEFREE An analysis of pleiotropic genes identified two new susceptibility genes for SSc (NF-κB and PLCL2) and confirmed the IRF8 locus. 25880423 2015
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.020 GeneticVariation disease BEFREE We also observed associations between SSc and rs6932056 in TNFAIP3 and rs2280381 in IRF8 (P = 0.0000095 and P = 0.0030, respectively), both of which displayed associations with SSc in a European population. 23124809 2013