IRF8, interferon regulatory factor 8, 3394

N. diseases: 149; N. variants: 20
Disease: Solid Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.030 PosttranslationalModification phenotype BEFREE As reported by others and our group, IRF8 expression is silenced by DNA methylation in both human solid tumors and hematological malignancies. 30466106 2018
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.030 Biomarker phenotype BEFREE Interferon regulatory factor-8 (IRF8), originally identified as a leukemic tumor suppressor, can also exert anti-neoplastic activities in solid tumors. 26008967 2015
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.030 Biomarker phenotype BEFREE Taken together, our data suggest that IRF8 is both an essential regulator in Fas-mediated apoptosis pathway and a metastasis suppressor in solid tumors and that metastatic tumor cells use DNA hypermethylation to repress IRF8 expression to evade apoptotic cell death and to acquire a metastatic phenotype. 17409439 2007