In vivo experiments conducted with tumor bearing nude Balb/c mice confirm the efficacy of Cu@CPP-800 as a very promising NIR-driven phototherapy agent for cancer treatment.
We present a case of an infant with CPP and significant diffuse leptomeningeal contrast enhancement at diagnosis, which spontaneously resolved after removal of the primary tumor.
The sequential delivery vesicles showed the anticipated three-layered TEM structure and dual-convertible (surface charge- and particle size-reversible) features in the tumor environment (pH 6.5), which guaranteed the sequential release of siVEGF-CPPs and PTX in the tumor extracellular environment and tumor cells, respectively.