|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
IDE inhibitors to treat diabetes, therefore, should prevent IDE-mediated insulin degradation, but not glucagon degradation, in contrast with traditional modes of enzyme inhibition.
|
31086331 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
BACKGROUND Insulin-degrading enzyme (IDE) is an important regulator for Ab clearance and diabetes.
|
29680859 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
As evidence indicates potential roles for IDE in diabetes and AD, understanding the mechanisms regulating IDE expression may be important in developing new treatment strategies.
|
29940507 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insulin degrading enzyme (IDE), a metalloprotease that degrades amyloid-β (Aβ) peptides and insulin, is associated with Alzheimer's disease and diabetes.
|
30133282 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insulin degrading enzyme (IDE) plays key roles in degrading peptides vital in type two diabetes, Alzheimer's, inflammation, and other human diseases.
|
29596046 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insulin-degrading enzyme (IDE) is a ubiquitous zinc peptidase of the inverzincin family, which has been initially discovered as the enzyme responsible for insulin catabolism; therefore, its involvement in the onset of diabetes has been largely investigated.
|
28635330 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
HHEX_23 and IDE_9 were genotyped, and diabetes (here including type 2 diabetes and prediabetes) was assessed.
|
26173052 |
2015 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several non-synonymous genetic mutations of IDE gene have been recently associated with susceptibility to both diabetes and Alzheimer's diseases.
|
24059301 |
2014 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition to suggesting research targets such as the IDE and SORCS1 genes, which are implicated in both AD and diabetes, LEARn suggests specific mechanisms for pre-disease remediation, based on nutritional adjustment of aberrant DNA methylation and oxidation.
|
22555376 |
2012 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insulin-degrading enzyme (IDE) can degrade insulin and amyloid-β, peptides involved in diabetes and Alzheimer's disease, respectively.
|
21185309 |
2011 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We can conclude that variations in IDE might contribute to diabetes susceptibility in the Korean population.
|
17913278 |
2008 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CDKAL1 and HHEX/IDE diabetes-associated alleles are associated with decreased pancreatic beta-cell function, including decreased beta-cell glucose sensitivity that relates insulin secretion to plasma glucose concentration.
|
17804762 |
2007 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, five positional candidate genes for diabetes and related complications are located in our linkage region (the pituitary adenylate cyclase activating polypeptide (PACAP in 18p11); the peroxisome proliferator-activated receptor gamma coactivator 1 (PPARGC1 in 4p15); PTEN, PPP1R5, and IDE located in 10q23.
|
17548123 |
2007 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.
|
15039230 |
2004 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the absence of convincing support for this association from linkage partitioning or analyses of continuous measures of glycemia, we conclude that analysis of over 2,400 samples provides no compelling evidence that variation in IDE contributes to diabetes susceptibility in humans.
|
12716770 |
2003 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The evidence presented supports the possibility that IDE is a susceptibility gene for diabetes in populations of European descent.
|
12765971 |
2003 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats.
|
10958757 |
2000 |