Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
IDE inhibitors to treat diabetes, therefore, should prevent IDE-mediated insulin degradation, but not glucagon degradation, in contrast with traditional modes of enzyme inhibition.
|
31086331 |
2019 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
As evidence indicates potential roles for IDE in diabetes and AD, understanding the mechanisms regulating IDE expression may be important in developing new treatment strategies.
|
29940507 |
2018 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Insulin degrading enzyme (IDE), a metalloprotease that degrades amyloid-β (Aβ) peptides and insulin, is associated with Alzheimer's disease and diabetes.
|
30133282 |
2018 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Insulin degrading enzyme (IDE) plays key roles in degrading peptides vital in type two diabetes, Alzheimer's, inflammation, and other human diseases.
|
29596046 |
2018 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
BACKGROUND Insulin-degrading enzyme (IDE) is an important regulator for Ab clearance and diabetes.
|
29680859 |
2018 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Insulin-degrading enzyme (IDE) is a ubiquitous zinc peptidase of the inverzincin family, which has been initially discovered as the enzyme responsible for insulin catabolism; therefore, its involvement in the onset of diabetes has been largely investigated.
|
28635330 |
2017 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
HHEX_23 and IDE_9 were genotyped, and diabetes (here including type 2 diabetes and prediabetes) was assessed.
|
26173052 |
2015 |
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Several non-synonymous genetic mutations of IDE gene have been recently associated with susceptibility to both diabetes and Alzheimer's diseases.
|
24059301 |
2014 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition to suggesting research targets such as the IDE and SORCS1 genes, which are implicated in both AD and diabetes, LEARn suggests specific mechanisms for pre-disease remediation, based on nutritional adjustment of aberrant DNA methylation and oxidation.
|
22555376 |
2012 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Insulin-degrading enzyme (IDE) can degrade insulin and amyloid-β, peptides involved in diabetes and Alzheimer's disease, respectively.
|
21185309 |
2011 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
One hypothesis is that the link between DM and AD is related to the function of insulin-degrading enzyme (IDE), an enzyme that degrades not only insulin and pancreatic amylin but also beta-amyloid (Abeta).
|
18346114 |
2009 |
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We can conclude that variations in IDE might contribute to diabetes susceptibility in the Korean population.
|
17913278 |
2008 |
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Interestingly, five positional candidate genes for diabetes and related complications are located in our linkage region (the pituitary adenylate cyclase activating polypeptide (PACAP in 18p11); the peroxisome proliferator-activated receptor gamma coactivator 1 (PPARGC1 in 4p15); PTEN, PPP1R5, and IDE located in 10q23.
|
17548123 |
2007 |
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
CDKAL1 and HHEX/IDE diabetes-associated alleles are associated with decreased pancreatic beta-cell function, including decreased beta-cell glucose sensitivity that relates insulin secretion to plasma glucose concentration.
|
17804762 |
2007 |
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.
|
15039230 |
2004 |
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In the absence of convincing support for this association from linkage partitioning or analyses of continuous measures of glycemia, we conclude that analysis of over 2,400 samples provides no compelling evidence that variation in IDE contributes to diabetes susceptibility in humans.
|
12716770 |
2003 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
The evidence presented supports the possibility that IDE is a susceptibility gene for diabetes in populations of European descent.
|
12765971 |
2003 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats.
|
10958757 |
2000 |