IDE, insulin degrading enzyme, 3416

N. diseases: 71; N. variants: 19
Disease: Hyperglycemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.020 AlteredExpression disease BEFREE The loss of insulin-induced regulation of IDE activity under hyperglycaemia may contribute to the reduced insulin extraction and peripheral hyperinsulinaemia in type 2 diabetes. 19396426 2009
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.020 GeneticVariation disease BEFREE Congenic rats with the IDE: GK allele displayed post-prandial hyperglycemia, reduced lipogenesis in fat cells, blunted insulin-stimulated glucose transmembrane uptake and reduced insulin degradation in isolated muscle. 10958757 2000