IDE, insulin degrading enzyme, 3416

N. diseases: 71; N. variants: 19
Disease: Memory impairment ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.020 AlteredExpression phenotype BEFREE However, exercise training improved the spatial learning and memory deficits, reduced both plaque load and sAβ<sub>1-42</sub> levels, and up-regulated expression of NEP, IDE, and LRP-1 in the hippocampus of Aβ<sub>1-42</sub>-treated animals. 29948724 2018
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.020 AlteredExpression phenotype BEFREE STZ (ICV) treated rats had shown memory impairment along with a significant decrease in IR signaling molecules (IR, pIRS-1, pAkt, and pGSK-3α/β expression) and IDE expression in both hippocampus and cerebral cortex. 27730514 2017