IDH1, isocitrate dehydrogenase (NADP(+)) 1, 3417

N. diseases: 399; N. variants: 10
Disease: WHO Grade III Glioma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4287997
Disease: WHO Grade III Glioma
WHO Grade III Glioma 		0.040 GeneticVariation disease BEFREE Possible underlying mechanisms include the higher prevalence of IDH mutations in WHO grade III glioma, which might sensitize to the metabolic drug metformin. 30091464 2019
CUI: C4287997
Disease: WHO Grade III Glioma
WHO Grade III Glioma 		0.040 GeneticVariation disease BEFREE Impact of gross total resection in patients with WHO grade III glioma harboring the IDH 1/2 mutation without the 1p/19q co-deletion. 27401154 2016
CUI: C4287997
Disease: WHO Grade III Glioma
WHO Grade III Glioma 		0.040 GeneticVariation disease BEFREE For patients with IDH1 mutant anaplastic glioma, the absence of contrast enhancement was associated with longer progression-free survival (P = .038, hazard ratio = 0.473) and overall survival (P = .043, hazard ratio = 0.436). 26316565 2015
CUI: C4287997
Disease: WHO Grade III Glioma
WHO Grade III Glioma 		0.040 GeneticVariation disease BEFREE However, patients with secondary anaplastic glioma and IDH mutation had a significantly improved outcome. 23015095 2012