IDH2, isocitrate dehydrogenase (NADP(+)) 2, 3418

N. diseases: 380; N. variants: 15
Disease: Breast Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.160 Biomarker disease BEFREE Further functional studies to decipher the role of IDH2 and its mechanism of action as a driver of BC progression and LVI are warranted. 31599393 2020
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.160 AlteredExpression disease BEFREE However, even wild-type IDH1 and IDH2, notably under shifts toward reductive carboxylation glutaminolysis or changes in other enzymes, lead to "intermediate" 0.01-0.1 mM 2HG levels, e.g. in breast carcinoma, compared to 10-8 M in non-cancer cells. 31847543 2020
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.160 AlteredExpression disease BEFREE However, the expression levels of the IDH protein and their biological function in human breast cancer remain largely unknown. 29661250 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.160 GeneticVariation disease BEFREE Solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms (solid papillary carcinomas with reverse polarity) harbour recurrent mutations affecting IDH2 and PIK3CA: a validation cohort. 29603332 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.160 GeneticVariation disease BEFREE IDH2 Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear Polarity. 27913435 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.160 Biomarker disease BEFREE Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells. 26007236 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.160 Biomarker disease HPO