IDH2, isocitrate dehydrogenase (NADP(+)) 2, 3418

N. diseases: 380; N. variants: 15
Disease: WHO Grade III Glioma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4287997
Disease: WHO Grade III Glioma
WHO Grade III Glioma 		0.020 GeneticVariation disease BEFREE Possible underlying mechanisms include the higher prevalence of IDH mutations in WHO grade III glioma, which might sensitize to the metabolic drug metformin. 30091464 2019
CUI: C4287997
Disease: WHO Grade III Glioma
WHO Grade III Glioma 		0.020 GeneticVariation disease BEFREE However, patients with secondary anaplastic glioma and IDH mutation had a significantly improved outcome. 23015095 2012