IFNA1, interferon alpha 1, 3439

N. diseases: 662; N. variants: 6
Disease: Arthritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003864
Disease: Arthritis
Arthritis 		0.050 Biomarker disease BEFREE Both control mice and mice devoid of IFNAR-signaling in T helper cells were protected from arthritis by IFN-α. 29515584 2018
CUI: C0003864
Disease: Arthritis
Arthritis 		0.050 Biomarker disease BEFREE First, greater levels of IL-12/23p40, IFN-γand IL-17A were confirmed in supernatants of lipopolysaccharide (LPS)-stimulated TNFRp55-/-splenocytes obtained on arthritis onset (day 14 after Ye infection). 29494692 2018
CUI: C0003864
Disease: Arthritis
Arthritis 		0.050 Biomarker disease BEFREE In conclusion, we demonstrate that type I IFN can prevent joint inflammation by downregulating antigen-specific cellular immunity. 21469099 2011
CUI: C0003864
Disease: Arthritis
Arthritis 		0.050 Biomarker disease BEFREE Furthermore, the ACPA response in individuals without arthritis and inflammation was not related to an increase of type I IFN. 19933783 2010
CUI: C0003864
Disease: Arthritis
Arthritis 		0.050 Biomarker disease BEFREE These in vitro data suggest a therapeutic role for IFN-a in the treatment of arthritis through upregulation of critical cytokine antagonists. 12734885 2003