|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data provide support for the endocannabinoid system in mediating and modulating heightened pain responding associated with IFNα-induced depression.
|
31505257 |
2019 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Results show that higher apoptosis during proliferation observed upon treatment of cells with baseline serum, and lower neuronal differentiation observed upon treatment with serum after 4 weeks of IFN-α, were predictive of later development of IFN-α-induced depression (odds ratio = 1.26, p = 0.06, and = 0.80, p = 0.01, respectively).
|
31207337 |
2019 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, its effects on neuropsychiatric manifestations have yet to be carefully assessed, even though IFNα has been associated with induction of depression.
|
31474191 |
2019 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment-emergent depression is a common complication in patients with chronic hepatitis C virus (HCV) infection undergoing antiviral combination therapy with IFN-α and ribavirin.
|
31332697 |
2019 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, it could be potential target therapies in IFN-ainduced depression.
|
31502579 |
2019 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Deficiency of the AIM2-ASC Signal Uncovers the STING-Driven Overreactive Response of Type I IFN and Reciprocal Depression of Protective IFN-γ Immunity in Mycobacterial Infection.
|
29255077 |
2018 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results of the study support the theory that IFN-induced depression is associated with a complex pathophysiological background, including serotonergic and dopaminergic neurotransmission as well as glucocorticoid and neurotrophic factors.
|
26721949 |
2016 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated whether indoleamine 2,3-dioxygenase1 (IDO1)-mediated tryptophan (TRP) metabolism plays a critical role in depression occurring as a side effect of IFN-α therapy.
|
27436416 |
2016 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggested that p11 might be a potential regulator on 5-HTR1b and 5-HTR4 as well as a predictor of or a therapeutic target for IFN-α-induced depression.
|
26821757 |
2016 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
LMD diagnoses were not cross-checked with medical records and IFN-induced depression was measured with a self-report scale only.
|
26001668 |
2015 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consequently, the upregulation of selective DRIIs, production of inflammatory cytokines and inhibition of neuronal plasticity may be involved in the pathogenesis of IFN-associated depression.
|
24391741 |
2013 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
To further explore mechanisms of IFN-α-induced depression and establish associated genetic risk factors, single nucleotide polymorphisms in genes encoding proteins previously implicated in IFN-α-induced depression were explored in two self-reported ethnic groups, Caucasians (n=800) and African Americans (n=232), participating in a clinical trial on the impact of three pegylated IFN-α treatment regimens on sustained viral response in patients with chronic hepatitis C. Before treatment, all subjects were free of psychotropic medications and had a score ≤20 on the Center for Epidemiologic Studies Depression Scale (CES-D), which was used to assess depressive symptom severity throughout the study.
|
21691274 |
2012 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Depression and fatigue during chronic IFN-α administration were associated with alterations in the expression (OAS2) and transcriptional control (CREB/ATF) of genes linked to behavioral disorders including CFS and major depression, further supporting an immune contribution to these diseases.
|
22152193 |
2012 |