IFNA1, interferon alpha 1, 3439

N. diseases: 662; N. variants: 6
Disease: Rotavirus Infections ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0035869
Disease: Rotavirus Infections
Rotavirus Infections 		0.010 Biomarker group BEFREE Although increased levels of systemic type I interferon (IFNalpha and beta) correlate with accelerated resolution of rotavirus disease, multiple rotavirus strains, including rhesus rotavirus (RRV), have been demonstrated to antagonize type I IFN production in a variety of epithelial and fibroblast cell types through several mechanisms, including degradation of multiple interferon regulatory factors by a viral nonstructural protein. 20532161 2010