|
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using cohorts of HIV-infected and HIV-uninfected individuals with latent Mtb infection (LTBI) and with active TB disease, we stimulated peripheral blood mononuclear cells (PBMC) for 6 hours with Mtb peptide pools and evaluated co-expression profiles of the inhibitory receptors BTLA, CTLA-4, and PD-1 on IFN-γ<sup>+</sup>/TNF-α<sup>+</sup> Mtb-specific CD4 T cells.
|
31497018 |
2019 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A type 1 IFN gene signature score ≥5.61 displayed high sensitivity (100%) and specificity (91%) for identification of active TB.
|
30336493 |
2018 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We sought to identify immune markers in Mtb-specific IFN-γ<sup>+</sup>CD4<sup>+</sup> T cells and hypothesized that expression of caspase-3 Mtb-specific CD4<sup>+</sup> T cells would be associated with ATB.
|
29983703 |
2018 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that increased cAMP inhibits IFN-g production through PKA type I pathway in tuberculosis infection.
|
29438524 |
2018 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Highest diagnostic accuracies for active TB (AUC ≥ 0.91) were achieved for: (i) CD27 within IFN-γ<sup>+</sup>TNF-α<sup>+</sup>CD4<sup>+</sup> T-cells in response to ESAT-6/CFP-10, (ii) CD27 and CCR4 markers together within IFN-γ<sup>+</sup>CD4<sup>+</sup> T-cells in response to PPD, and (iii) CD27 MFI ratio performed on IFN-γ<sup>+</sup>TNF-α<sup>+</sup>CD4<sup>+</sup> T-cells after ESAT-6/CFP-10 stimulation.
|
30687314 |
2018 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis.
|
29161093 |
2018 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results indicate that BCG prime-boost strategy might be a promising measure for the prevention against late persistent TB infection by induction of IFN-γ<sup>+</sup> T<sub>EM</sub> and IL-2<sup>+</sup> T<sub>CM</sub> cells in the lung, which can be used as alternative biomarkers for guiding the clinical practice and future development of TB vaccine for adults.
|
30425711 |
2018 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further analysis showed that positive correlation between IP-10 and IFN-<i>γ</i> existed in healthy and tuberculosis monkeys.
|
28512637 |
2017 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, our data support a model in which suppression of alternative macrophage activation by type I IFN during M. tuberculosis infection, in the absence of IFN-γ signaling, contributes to host protection.
|
27849167 |
2016 |
|
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our findings demonstrate that IFN-α employs distinct pathways for regulating IL-1β production and reveal that in the case of M.tb infection, the induction of IFN-α and IFN-γ might be associated with M.tb immune escape and disease progression in infected humans.-Ma, J., Yang, B., Yu, S., Zhang, Y., Zhang, X., Lao, S., Chen, X., Li, B., Wu, C. Tuberculosis antigen-induced expression of IFN-α in tuberculosis patients inhibits production of IL-1β.
|
24675363 |
2014 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Determination of susceptibility to tuberculosis with polymorphism of IFN-gammaR1 gene.
|
16233916 |
2006 |