Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The clinical observation that AA can occur after viral infection or IFN-α administration implies that IFN-α-producing plasmacytoid dendritic cells (pDCs) may be involved in the AA pathogenesis.
|
31431342 |
2020 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFN responses to viral infection are necessary to establish intrinsic antiviral state, but if unchecked can lead to heightened inflammation.
|
31548332 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Type I interferons (IFNs) (IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties, including induction by viral infection, activation of shared signaling pathways, and transcriptional programs.
|
30995506 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Mx proteins are antiviral GTPases, which are induced by type I IFN and virus infection.
|
30195710 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The interaction of FKBP8 with VISA, retinoic acid inducible protein 1 (RIG-I), and IFN regulatory factor 3 (IRF3) was confirmed during viral infection in mammalian cells by coimmunoprecipitation.
|
30267576 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Human UBL4A/GdX, encoding an ubiquitin-like protein, was shown in this study to be upregulated by viral infection and IFN stimulation.
|
31451677 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Using pharmacological and genetic approaches, we show that lactate reduction by lactate dehydrogenase A (LDHA) inactivation heightens type I IFN production to protect mice from viral infection.
|
31155231 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of the pathogen-associated molecular patterns (PAMPs) in the form of viral double-stranded RNA (dsRNA) motifs to induce expression of type 1 interferons (IFN1) (IFNα and IFNβ) and other pro-inflammatory cytokines during the early stage of viral infection.
|
31379819 |
2019 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
<b>Conclusions:</b> Dysregulated expression of IFN-dependent pathways after respiratory viral infections is a defining immunophenotypic feature of AVB-susceptible infants and a subset of children.
|
30562046 |
2019 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IFN α and β are two cytokines, which have a major activity in the innate immune system against viral infections.
|
30378208 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, this research on CoBoIFN-ω not only extends and improves consensus IFN research, but also reveals that CoBoIFN-ω has the potential to be used in the therapy of bovine viral diseases.
|
30576951 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Commercially, IFN-α has been approved to treat many chronic viral diseases as well as a variety of cancers and different types of leukemia.
|
30543053 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
By extension, IFN-αβ or combination therapy may need to be used cautiously to treat viral infections in clinical settings.
|
31355779 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Type I interferon (IFN-I) is critical for antiviral defense, and plasmacytoid dendritic cells (pDCs) are a predominant source of IFN-I during virus infection. pDC-mediated antiviral responses are stimulated upon physical contact with infected cells, during which immunostimulatory viral RNA is transferred to pDCs, leading to IFN production via the nucleic acid sensor TLR7.
|
31003939 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFN-α as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters.
|
31784575 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Infectious bursal disease virus (IBDV) infection triggers the induction of type I IFN, which is mediated by melanoma differentiation-associated protein 5 recognition of the viral genomic double-stranded RNA (dsRNA).
|
29979632 |
2019 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Among the 12 IFNα subtypes, IFNα1 has a uniquely low affinity for IFNAR2 (<100 × of the other IFNα subtypes) and commensurately weak antiviral activity, suggesting an undefined function distinct from suppression of viral infections.
|
30920934 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFN-stimulated gene expression establishes the antiviral state, limiting viral infection in IFN-α-stimulated microenvironments.
|
30282499 |
2018 |
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Interferon type III (IFN-λ), which includes IL28, IL29, and IL28R, and affects the outcome of viral infections, might be complicated in the progression of HAM/TSP.
|
29990995 |
2018 |
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A detailed immunological investigation of these patients revealed impaired responses to type I IFN, IL-10, IL-12 and IL-23, which are associated with increased susceptibility to mycobacterial and/or viral infections.
|
29725107 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The nine-member IFN regulatory factor (IRF) family, first discovered in the context of transcriptional regulation of type I IFN genes following viral infection, are pivotal for the regulation of the IFN responses.
|
28963109 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The contribution of distinct central nervous system (CNS) resident cells to protective alpha/beta interferon (IFN-α/β) function following viral infections is poorly understood.
|
29491163 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Polymorphisms in these genes may cause chronic dysregulated IFN signaling in islets, characterized by hyperexpression of IFN-I, the IFN gene signature, and major histocompatibility complex class I during viral infection.
|
29369915 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Type III IFN (IFN-λ) is the dominant frontline response over type I IFN in human normal intestinal epithelial cells upon viral infection, this response being mimicked by the dsRNA analog poly-IC.
|
30349642 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Despite its beneficial effects in viral infections IFNα has been reported to be associated with several autoimmune diseases including autoimmune thyroid disease, systemic lupus erythematosus, rheumatoid arthritis, primary biliary cholangitis, and recently emerged as a major cytokine that triggers Type 1 Diabetes.
|
30115527 |
2018 |