IFNA1, interferon alpha 1, 3439

N. diseases: 662; N. variants: 6
Disease: Chronic viral hepatitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0276623
Disease: Chronic viral hepatitis
Chronic viral hepatitis 		0.050 Biomarker disease BEFREE The use of pegylated interferon-α (pegIFN-α) has replaced unmodified recombinant IFN-α for the treatment of chronic viral hepatitis. 24569457 2014
CUI: C0276623
Disease: Chronic viral hepatitis
Chronic viral hepatitis 		0.050 Biomarker disease BEFREE The induction of TLR7 responsiveness of monocytes by IFNα in vivo in HCV patients is relevant for the development of TLR7 agonists that are currently under development as a promising immunotherapeutic compounds to treat chronic viral hepatitis. 25014880 2014
CUI: C0276623
Disease: Chronic viral hepatitis
Chronic viral hepatitis 		0.050 Biomarker disease BEFREE IFN-α is widely used for the treatment of chronic viral hepatitis and malignancies. 22422884 2012
CUI: C0276623
Disease: Chronic viral hepatitis
Chronic viral hepatitis 		0.050 AlteredExpression disease BEFREE These results hold promise for the development of a gene therapy treatment for chronic viral hepatitis based on liver-restricted expression of IFN-alpha2. 10775620 2000
CUI: C0276623
Disease: Chronic viral hepatitis
Chronic viral hepatitis 		0.050 Biomarker disease BEFREE The 23 patients with the IFN-alpha 2b gene and chronic viral hepatitis included 10 who developed antibodies against IFN after treatment with recombinant IFN-alpha 2a. 1515568 1992