|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Altogether, we establish a direct role for type I IFN/USP18 signaling in the maintenance of total and virus-specific Mem and provide a new mechanism for the reduced survival of these populations during primary HIV-1 infection.
|
31658294 |
2019 |
|
HIV-1 infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To investigate the contribution of SAMHD1 to HIV-1 infection in vivo and its relationship with IFN response, the expression of SAMHD1 and IFN-related pathways was evaluated in HIV-1-infected patients.
|
30564919 |
2019 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV-1 infection in macrophages.
|
29437254 |
2018 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
During infection Type 1 IFNs normally play an essential role in viral clearance, but in vivo IFN-α only has a modest impact on HIV-1 infection, suggesting its possible targeting by HIV.
|
29580840 |
2018 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we report studies using a monoclonal antibody to block IFN-α/β receptor 1 (IFNAR1) signaling during persistent HIV-1 infection in humanized mice (hu-mice).
|
28614789 |
2017 |
|
HIV-1 infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, extensive colocalization of viral Gag and CD169 was observed in lymph nodes of infected pigtailed macaques, suggesting productive infection of CD169<sup>+</sup> cells <i>in vivo</i> Treatment of dendritic cell (DC)-T cell cocultures with IFN-α upregulated CD169 expression on DCs and rescued HIV-1 infection of CD4<sup>+</sup> T cells in <i>trans</i>, suggesting that HIV-1 exploits CD169 to attenuate type I IFN-induced restrictions.
|
28794041 |
2017 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Altogether, our results demonstrate that IFN-inducible LY6E promotes HIV-1 entry and replication and highlight a positive regulatory role of IFN-induced proteins in HIV-1 infection.
|
28130445 |
2017 |
|
HIV-1 infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IFN-stimulated gene expression is independent of the IFNL4 genotype in chronic HIV-1 infection.
|
27558125 |
2016 |
|
HIV-1 infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Altogether, these findings identify HMGB1 as a trigger for IFN-α-mediated TRAIL expression at the surface of pDCs and NK cells, and they suggest a novel mechanism of innate control of HIV-1 infection.
|
26871575 |
2016 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Plasmacytoid dendritic cells (pDCs) are the major source of type I IFN (IFN-I) in response to human immunodeficiency virus type 1 (HIV-1) infection. pDCs are rapidly activated during HIV-1 infection and are implicated in reducing the early viral load, as well as contributing to HIV-1-induced pathogenesis.
|
25972534 |
2015 |
|
HIV-1 infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that the presence of the IFN+874A allele confers susceptibility to HIV-1 infection and a decrease in the number of CD4+ T lymphocytes.
|
25802474 |
2015 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, by comparing gene expression profiles in cell lines that differ in their ability to support the inhibitory action of IFN-α at early steps of the HIV-1 replication cycle, we identify myxovirus resistance 2 (MX2) as an interferon-induced inhibitor of HIV-1 infection.
|
24121441 |
2013 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we use both ectopic expression and gene-silencing experiments to define the human dynamin-like, IFN-induced myxovirus resistance 2 (MX2, also known as MXB) protein as a potent inhibitor of HIV-1 infection and as a key effector of IFN-α-mediated resistance to HIV-1 infection.
|
24048477 |
2013 |
|
HIV-1 infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to obtain regulated expression of IFN-alpha that responds to HIV-1 infection, a recombinant SV40 vector was designed that carries the human IFN-alpha2 cDNA under the control of the HIV-1 long terminal repeat (LTR) (SV[HIVLTR]IFN).
|
14565857 |
2003 |