IFNA1, interferon alpha 1, 3439

N. diseases: 28; N. variants: 0
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.400 Therapeutic disease CTD_human These results suggest that IFN-alpha gene therapy is a promising strategy to treat HCC patients who have concomitant liver cirrhosis. 18665156 2008
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.400 Therapeutic disease CTD_human These results suggest that IFN-alpha gene therapy is a promising strategy to treat HCC patients who have concomitant liver cirrhosis. 18665156 2008
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.400 Therapeutic disease CTD_human Combination therapy with PEG-IFN-alpha and 5-FU inhibits HepG2 tumour cell growth in nude mice by apoptosis of p53. 17971768 2007
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Therapeutic disease CTD_human A biochemotherapy regimen with concurrent administration of cisplatin, vinblastine, temozolomide (Temodal), interferon-alfa and interleukin-2 for metastatic melanoma: a phase II study. 16432458 2006
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.400 Therapeutic disease CTD_human Measuring the expression levels of IFN receptors, and their ability to be up-regulated, may be a promising method for selecting HCC patients for this type of combination therapy. 17088986 2006
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Therapeutic disease CTD_human Randomized trial of dacarbazine versus bleomycin, vincristine, lomustine and dacarbazine (BOLD) chemotherapy combined with natural or recombinant interferon-alpha in patients with advanced melanoma. 16034308 2005
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Therapeutic disease CTD_human Low-dose outpatient chemobiotherapy with temozolomide, granulocyte-macrophage colony stimulating factor, interferon-alpha2b, and recombinant interleukin-2 for the treatment of metastatic melanoma. 16260693 2005
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Therapeutic disease CTD_human Temozolomide in combination with interferon-alfa versus temozolomide alone in patients with advanced metastatic melanoma: a randomized, phase III, multicenter study from the Dermatologic Cooperative Oncology Group. 16260697 2005
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.400 Therapeutic disease CTD_human To explore a new strategy for effective and economical anti-virus therapy for HBV infection, we conducted a sequence administration of lamivudine and interferon alpha 1b to evaluate its effects on HBV replication and rebound as well as YMDD mutation induced by lamivudine. 15504288 2004
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Therapeutic disease CTD_human The prognostic role of CD4+ and CD8+ lymphocytes during chemoimmunotherapy in metastatic melanoma. 15577320 2004
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Therapeutic disease CTD_human Biochemotherapy in patients with advanced vulvovaginal mucosal melanoma. 15577323 2004
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Therapeutic disease CTD_human [Chemoimmunotherapy with dacarbazine and aranose combined with interferon-alpha in disseminated cutaneous melanoma]. 15176220 2004
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.380 Therapeutic disease CTD_human Dual therapeutic effects of interferon-alpha gene therapy in a rat hepatocellular carcinoma model with liver cirrhosis. 18665156 2008
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.360 Therapeutic disease CTD_human Impact of interferon-alpha in combined chemoradioimmunotherapy for pancreatic adenocarcinoma (CapRI): first data from the immunomonitoring. 17198089 2007
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.360 Therapeutic disease CTD_human [Endocrine tumors of the pancreas (EPTs) in multiple endocrine neoplasia (MEN1): up-date on prognostic factors, diagnostic procedures and treatment]. 17961653 2007
CUI: C0023493
Disease: Adult T-Cell Lymphoma/Leukemia
Adult T-Cell Lymphoma/Leukemia 		0.350 Therapeutic disease CTD_human Expression profiles of adult T-cell leukemia-lymphoma and associations with clinical responses to zidovudine and interferon alpha. 20370541 2010
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.340 Therapeutic disease CTD_human IFN-alpha prevents the growth of pre-neoplastic lesions and inhibits the development of hepatocellular carcinoma in the rat. 14633663 2004
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms 		0.330 Biomarker phenotype PSYGENET Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon-α-induced depression in patients with chronic hepatitis C. 21691274 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.330 Biomarker disease PSYGENET Depression and fatigue during chronic IFN-α administration were associated with alterations in the expression (OAS2) and transcriptional control (CREB/ATF) of genes linked to behavioral disorders including CFS and major depression, further supporting an immune contribution to these diseases. 22152193 2012
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.330 Therapeutic disease CTD_human In an effort to improve the therapeutic effect of a MAb-based regimen in colorectal carcinoma (CRC) patients, the effects of a combination of alpha-interferon (alpha-IFN), 5-fluorouracil (5-FU), granulocyte-macrophage colony-stimulating factor (GM-CSF) and mouse MAb17-1A was evaluated in 27 patients with metastatic disease. alpha-IFN was given s.c. once daily for 5 consecutive days and at days 4 and 5, 5-FU was administered as a daily i.v. bolus injection. 15289873 2004
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.330 Therapeutic group CTD_human IFN-alpha prevents the growth of pre-neoplastic lesions and inhibits the development of hepatocellular carcinoma in the rat. 14633663 2004
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.320 Therapeutic group CTD_human Impact of interferon-alpha in combined chemoradioimmunotherapy for pancreatic adenocarcinoma (CapRI): first data from the immunomonitoring. 17198089 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 Biomarker disease PSYGENET As a result, IL-6, IL-8 and IFN related pathways held twice to thrice the number of expected variants associated with BD. 25855618 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.310 Biomarker disease PSYGENET Depression and fatigue during chronic IFN-α administration were associated with alterations in the expression (OAS2) and transcriptional control (CREB/ATF) of genes linked to behavioral disorders including CFS and major depression, further supporting an immune contribution to these diseases. 22152193 2012
CUI: C0011993
Disease: Vipoma
Vipoma 		0.300 Therapeutic disease CTD_human [Endocrine tumors of the pancreas (EPTs) in multiple endocrine neoplasia (MEN1): up-date on prognostic factors, diagnostic procedures and treatment]. 17961653 2007