|
Pseudohyperkalemia Cardiff
|
0.100 |
Biomarker
|
disease |
BEFREE |
A total of 117 patients with CHC who failed to achieve SVR at the first IFN-based therapy and received a second IFN-based therapy were enrolled.
|
28389143 |
2018 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Subclinical hypothyroidism is common in children with CHC receiving treatment with pegylated IFN-α-2b and RBV, but in most cases is transient.
|
28953189 |
2018 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
<b>Methods:</b> We investigated the sPD-L1 levels in the sera of 80 genotype 1b Japanese patients with CHC who underwent 12 weeks of telaprevir (TVR)- or simeprevir (SMV)-based triple therapy followed by 12 weeks of dual therapy with pegylated IFN-α plus ribavirin.
|
28539815 |
2017 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
Biomarker
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) near IL28B (IFNλ3) are strongly associated with treatment response to IFNα therapy in chronic hepatitis C (CHC) patients.
|
25611696 |
2015 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cytopenia during interferon-based (IFN-based) therapy for chronic hepatitis C (CHC) often necessitates reduction of doses of drugs and premature withdrawal from therapy resulting in poor response to treatment.
|
25515861 |
2015 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The SNPs rs738409478 and rs2645424 were determined by real-time PCR in 478 patients with CHC (m/f: 314/164; mean age: 44.9 ± 10.7; GT1: 387, GT4: 91) who completed treatment with peg-IFN-α-2a/ribavirin.All had a pretreatment liver biopsy.
|
23870067 |
2014 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of IFN-γ-stimulated genes was induced in liver samples from patients with AHC, whereas expression of IFN-α-stimulated genes was induced in samples from patients with CHC.
|
22677194 |
2012 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A total of 55 patients were treated in a single center with PEG-IFNα-2a monotherapy for CHC and evaluated for variables predictive of the occurrence of HCC.
|
23258095 |
2012 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
Biomarker
|
disease |
BEFREE |
Combination therapy with PEG-IFN-α and RBV demonstrated good tolerability in CHC genotype 3 infection.
|
21706207 |
2011 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
Biomarker
|
disease |
BEFREE |
A common genetic variation near the IL28B gene has been found to affect the response to PEG-IFN plus ribavirin therapy for CHC.
|
22156487 |
2011 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
Biomarker
|
disease |
BEFREE |
We enrolled 145 consecutive Taiwanese patients with CHC receiving Peg-IFN α-2a plus ribavirin for the study.
|
21321200 |
2011 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although the expression levels of RIG-I and its adaptor molecule, IFN promoter-stimulator-1, were substantially enhanced in CHC B cells, dimerization and subsequent nuclear translocation of IRF-3 were not detectable.
|
20714117 |
2010 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
Biomarker
|
disease |
BEFREE |
The biochemical and virological responses to combined PEG-IFN and RBV therapy might be similar in CHC patients with or without occult HBV infection.
|
19817959 |
2010 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The efficacy and immune response of RBV+PEG-IFN-alpha2b using induction approach with CPIT (novel combination treatment: NCT) in 7 CHC patients with genotype 1b and high viral load were evaluated.
|
19441887 |
2009 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together with previous findings, our data support the concept that activation of the endogenous IFN system in CHC not only is ineffective in clearing the infection but also may impede the response to therapy, most likely by inducing a refractory state of the IFN signaling pathway.
|
18467494 |
2008 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Weight affect relapse rates in latinos with genotype 2/3 chronic hepatitis C (CHC) treated with peg IFN alfa-2a (Pegasys) 180 mcg/week and 800 mg daily of ribavirin for 24 weeks.
|
18649339 |
2008 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
Biomarker
|
disease |
BEFREE |
We retrospectively analyzed the genetic differences of CHC patients that are associated with IFN/ribavirin responses.
|
16886895 |
2006 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
Biomarker
|
disease |
BEFREE |
A 67-year-old man, who had been under treatment for hypertension and diabetes mellitus, was admitted to our hospital for peg-IFN-alpha2b plus ribavirin treatment for CHC.
|
17287904 |
2006 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
Biomarker
|
disease |
BEFREE |
To evaluate the pharmacodynamics of alb-IFN during the Phase I/II study conducted in patients with chronic hepatitis C (CHC) who had previously failed IFN-alpha-containing regimens, ISG induction was evaluated in peripheral blood and compared with antiviral response.
|
17302252 |
2006 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of type I IFN (IFN-alpha, -beta) and TLR-3 mRNAs, which are known to induce type I IFN, were significantly higher in portal tract and liver parenchyma as compared to AIH and CHC.
|
15856047 |
2005 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
Biomarker
|
disease |
BEFREE |
A prospective cohort study on SOCS-1 expression and clinical outcome was carried out in 77 patients with CHC who received IFN therapy.
|
15720527 |
2005 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three hundred and twenty-one CHC patients including virologic nonresponders to combination IFN plus RBV (n = 219) or IFN monotherapy (n = 47), and relapsers to combination therapy (n = 55) were randomized to receive PEG IFN alpha-2b 1.5 microg/kg per wk plus RBV 800 mg per day (Regimen A, n = 160) or PEG IFN alpha-2b 1.0 microg/kg per wk plus RBV 1,000-1,200 mg per day (Regimen B, n = 161) for 48 wks.
|
16279900 |
2005 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consecutive patients with CHC who had a complete biochemical response but relapse after a first course of 6 months of IFN with 3 million units (MU) given subcutaneously three times per week were enrolled in the study.
|
9828235 |
1998 |
|
Pseudohyperkalemia Cardiff
|
0.100 |
Biomarker
|
disease |
BEFREE |
To evaluate the efficacy of a long-term course of alpha-interferon (alpha-IFN) in the treatment of HCV-related mixed cryoglobulinaemia and to determine the impact of cryoglobulinaemia on therapeutic response to IFN in chronic hepatitis C (CHC) patients.
|
9431896 |
1997 |