|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic polymorphisms within the promoter of interferon-α receptor type-1 (IFNAR1) have been associated with the susceptibility to and the outcome of chronic hepatitis B virus (HBV) infection.
|
29713327 |
2018 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined the association of INFAR1 promoter polymorphisms with the phase of chronic HBV infection in a demographically characterized Caucasian cohort of 183 consecutive HBeAg-negative chronic HBV patients.
|
25939635 |
2015 |
|
Hepatitis B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that the polymorphic variant of IFNA1 (-2) gene is associated with chronic HBV infection, and high expression levels of the IFNAR1 gene and low levels of IFNA1 might contribute to the pathogenesis of chronic infection in these subjects.
|
27101083 |
2015 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of the IFNAR1-17470 and IL-10-592 cytokine variants with susceptibility to chronic hepatitis B viral infections in a Chinese population.
|
25501140 |
2014 |
|
Hepatitis B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study was aimed to determine the possible associations between oxidative stress and peripheral IFNAR expression in chronic HBV infection.
|
23663046 |
2013 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our research indicates that genetic polymorphisms of IFNAR-1 not only contribute to the determination of clearance or chronicity in the early stages of HBV exposure, but they also persistently influence pathogenesis over the long-term process of chronic HBV infection.
|
20565290 |
2010 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We previously demonstrated that two linked single nucleotide polymorphisms (SNPs) at -408 and -3 of type I interferon receptor 1 (IFNAR1) promoter are associated with susceptibility to chronic HBV infection.
|
19501422 |
2009 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This resulted in a nonsynonymous substitution in the extracellular region of IFNAR1 protein and correlated with susceptibility to chronic HBV infection.
|
18761606 |
2009 |
|
Hepatitis B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
When comparing HBV-HCC vs HCV-HCC, HBV-HCC/HCV-HCC vs non-viral (NV)-HCC, HBC-HCC vs NV-HCC, and HCV-HCC vs NV-HCC of the 58 non-redundant differentially expressed genes, only 6 genes (IKBKbeta, CREBBP, WNT10B, PRDX6, ITGAV, and IFNAR1) were found to be associated with hepatic carcinogenesis.
|
19893992 |
2009 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have evaluated the impact of two variants of the IFNAR1 gene on the outcome of HBV infection.
|
19103527 |
2008 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results showed that polymorphisms of IFNAR1 promoter may affect, at least in part, the outcomes of HBV infection.
|
17125879 |
2007 |