IFNB1, interferon beta 1, 3456

N. diseases: 426; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.560 GeneticVariation disease UNIPROT
CUI: C0038522
Disease: Subacute Sclerosing Panencephalitis
Subacute Sclerosing Panencephalitis 		0.010 Biomarker disease BEFREE Subacute sclerosing panencephalitis in a brother and sister. Therapeutic trial of fibroblast interferon. 6178588 1982
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.090 GeneticVariation group BEFREE The structural gene for Herpes simplex virus (HSV) thymidine kinase (Tk) was fused downstream of the 5'-flanking sequence (from -284 to +20; numbering relative to the putative transcription initiation site) of the cloned human interferon-beta 1 (IFN-beta 1) gene. 6310498 1983
CUI: C0024302
Disease: Reticulosarcoma
Reticulosarcoma 		0.010 Biomarker disease BEFREE Autogenous production of interferon-beta switches on HLA genes during differentiation of histiocytic lymphoma U937 cells. 6376119 1984
CUI: C0079744
Disease: Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma 		0.010 Biomarker disease BEFREE Autogenous production of interferon-beta switches on HLA genes during differentiation of histiocytic lymphoma U937 cells. 6376119 1984
CUI: C0334663
Disease: Histiocytic sarcoma
Histiocytic sarcoma 		0.010 Biomarker disease BEFREE Autogenous production of interferon-beta switches on HLA genes during differentiation of histiocytic lymphoma U937 cells. 6376119 1984
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.090 Biomarker group BEFREE Sensitivity in vitro of herpes simplex virus isolates to human fibroblast interferon. 3037288 1987
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 AlteredExpression group BEFREE Interferon-beta (IFN-beta) gene is transcriptionally activated following virus infection of various cell types such as fibroblasts. 2566973 1989
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE The gene that encodes the membrane-bound Mr 100,000 human melanoma-associated antigen (MAA) defined by mouse mAb 376.96, a leukocyte and fibroblast interferon-modulated glycoprotein having preferential distribution on melanoma and carcinoma cells, has been transfected into the mouse melanoma cell line B78H1 as a step toward molecular cloning and characterization of the MAA. 2302716 1990
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.310 Therapeutic disease CTD_human Protection from carcinogen-induced murine bladder carcinoma by interferons and an oral interferon-inducing pyrimidinone, bropirimine. 2297754 1990
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.310 Therapeutic disease CTD_human Protection from carcinogen-induced murine bladder carcinoma by interferons and an oral interferon-inducing pyrimidinone, bropirimine. 2297754 1990
CUI: C0007138
Disease: Carcinoma, Transitional Cell
Carcinoma, Transitional Cell 		0.300 Therapeutic disease CTD_human Protection from carcinogen-induced murine bladder carcinoma by interferons and an oral interferon-inducing pyrimidinone, bropirimine. 2297754 1990
CUI: C0027659
Disease: Neoplasms, Experimental
Neoplasms, Experimental 		0.300 Therapeutic phenotype CTD_human Protection from carcinogen-induced murine bladder carcinoma by interferons and an oral interferon-inducing pyrimidinone, bropirimine. 2297754 1990
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE This finding adds solid tumors to those tumor cell lines (acute lymphocytic leukemia, chronic myelogeneous leukemia) previously determined to lack the IFNA and IFNB genes (Diaz et al., Proc.Natl.Acad.Sci.USA, 85:5259-5263, 1988). 2295067 1990
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.090 Biomarker disease BEFREE The growth inhibitory effects of IFN-beta on the two lung cancer cell lines could not, however, be correlated with decreased amounts of c-myc mRNA. 2560625 1990
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.080 Biomarker disease BEFREE The growth inhibitory effects of IFN-beta on the two lung cancer cell lines could not, however, be correlated with decreased amounts of c-myc mRNA. 2560625 1990
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.080 Biomarker disease BEFREE The growth inhibitory effects of IFN-beta on the two lung cancer cell lines could not, however, be correlated with decreased amounts of c-myc mRNA. 2560625 1990
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.030 Biomarker phenotype BEFREE This finding adds solid tumors to those tumor cell lines (acute lymphocytic leukemia, chronic myelogeneous leukemia) previously determined to lack the IFNA and IFNB genes (Diaz et al., Proc.Natl.Acad.Sci.USA, 85:5259-5263, 1988). 2295067 1990
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia 		0.020 Biomarker disease BEFREE We report here homozygous or hemizygous deletions of the interferon-alpha and interferon-beta 1 genes in samples of leukemia cells from patients with lymphoblastic leukemia. 2294436 1990
CUI: C0016719
Disease: Friedreich Ataxia
Friedreich Ataxia 		0.010 GeneticVariation disease BEFREE Chamberlain et al. have assigned the gene for Friedreich ataxia (FA), a recessive neurodegenerative disorder, to chromosome 9, and have proposed a regional localization in the proximal short arm (9p22-cen), on the basis of linkage to D9S15 and to interferon-beta (IFNB), the latter being localized in 9p22. 2294745 1990
CUI: C0023418
Disease: leukemia
leukemia 		0.010 GeneticVariation disease BEFREE This finding adds solid tumors to those tumor cell lines (acute lymphocytic leukemia, chronic myelogeneous leukemia) previously determined to lack the IFNA and IFNB genes (Diaz et al., Proc.Natl.Acad.Sci.USA, 85:5259-5263, 1988). 2295067 1990
CUI: C0023448
Disease: Lymphoid leukemia
Lymphoid leukemia 		0.010 Biomarker disease BEFREE We report here homozygous or hemizygous deletions of the interferon-alpha and interferon-beta 1 genes in samples of leukemia cells from patients with lymphoblastic leukemia. 2294436 1990
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.010 GeneticVariation disease BEFREE This finding adds solid tumors to those tumor cell lines (acute lymphocytic leukemia, chronic myelogeneous leukemia) previously determined to lack the IFNA and IFNB genes (Diaz et al., Proc.Natl.Acad.Sci.USA, 85:5259-5263, 1988). 2295067 1990
CUI: C1961102
Disease: Precursor Cell Lymphoblastic Leukemia Lymphoma
Precursor Cell Lymphoblastic Leukemia Lymphoma 		0.010 Biomarker disease BEFREE We report here homozygous or hemizygous deletions of the interferon-alpha and interferon-beta 1 genes in samples of leukemia cells from patients with lymphoblastic leukemia. 2294436 1990
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE Our results reveal the following: (a) for those cases in which loss has occurred, the region of common loss lies on the short (p) arm of the chromosome; (b) loss of genetic information from the short arm of chromosome 9 occurs frequently in glial tumors of intermediate (anaplastic, grade III) and high (glioblastoma, grade IV) histological malignancy (10 of 20 cases) but not in tumors of low (grade II) histological malignancy (0 of 10 cases); (c) tumors with 9p deletions are hemi- or nullizygous for interferon beta-1 and the interferon alpha gene cluster; (d) cases of interferon nullizygosity occur exclusively among tumors of highest histological malignancy (glioblastoma). 1998958 1991