|
Anaplastic thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study study, human neural stem cells (hNSCs) that were genetically engineered to express cytosine deaminase (CD) and human interferon-β (IFN-β) were used for anaplastic thyroid cancer (ATC) treatment owing to their tumor-tropic properties and therapeutic effects.
|
31512776 |
2020 |
|
Pulmonary arterial hypertension
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mutually reinforcing effects of genetic variants and interferon-β 1a therapy for pulmonary arterial hypertension development in multiple sclerosis patients.
|
31798832 |
2020 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockout of IFN-β and IFNAR in mice abolished the preventive effects of polyI:C on caerulein-induced AP symptoms, which include pancreatic edema, neutrophil infiltration, the accumulation of reactive oxygen species (ROS), and inflammatory gene expression.
|
31130960 |
2019 |
|
Bone Marrow Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The most promising results are for interferon beta in human T cell leukaemia virus 1 associated myelopathy/tropical spastic paraparesis and glioma, and for fingolimod in acute ischaemic stroke and intracerebral haemorrhage.
|
31100209 |
2019 |
|
Diffuse Cerebral Sclerosis of Schilder
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this case study, it is suggested that interferon-β may induce long-term remission in relapsing Schilder disease and is therefore worth considering in this regard.
|
31662417 |
2019 |
|
Febrile Convulsions
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Age, gender distribution and CSF IL-12 and IFN- β levels did not differ, but CSF IL-10 levels were significantly lower in the FS group as compared to the control group (0.78 ± 4.5 pg/ml, versus 27 ± 29 pg/ml, p < 0.0001).
|
30658331 |
2019 |
|
Encephalitis, St. Louis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
On the basis of top differentially expressed genes between SLE and healthy controls, SLE patients with high levels of serum IFNβ clustered together while SLE patients with low levels of IFNβ clustered with healthy controls.
|
31153744 |
2019 |
|
Fatty Liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Mice fed a high-fat diet (HFD), an obesity-associated fatty liver model, showed increased expression of IFN-β with suppression of DNase II activity in their livers and developed not only hepatocyte apoptosis but also non-apoptotic hepatocyte death.
|
29855540 |
2019 |
|
Headache
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
A higher incidence of headache was found in patients treated with interferon beta.
|
30368222 |
2019 |
|
Herpes NOS
|
0.010 |
Biomarker
|
disease |
BEFREE |
In contrast, use of herpes antiviral drugs during rituximab treatment was similar to that of interferon beta and GA and lower than that of natalizumab (HR, 1.82 [1.34-2.46]) and fingolimod (HR, 1.71 [95% CI, 1.27-2.32]).
|
31589278 |
2019 |
|
Hyperemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The livers, lungs, and kidneys of nude mice in the IFN-β group displayed hyperemia, exudation, and pathological lesions, while those of nude mice in the IFN-β-MSCs group showed no abnormal changes.
|
30683475 |
2019 |
|
Pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
TLR3 Ligand PolyI:C Prevents Acute Pancreatitis Through the Interferon-β/Interferon-α/β Receptor Signaling Pathway in a Caerulein-Induced Pancreatitis Mouse Model.
|
31130960 |
2019 |
|
Tropical Spastic Paraparesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The most promising results are for interferon beta in human T cell leukaemia virus 1 associated myelopathy/tropical spastic paraparesis and glioma, and for fingolimod in acute ischaemic stroke and intracerebral haemorrhage.
|
31100209 |
2019 |
|
Rabies (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also show that RABV infection increased IFN-β production in MRC-5 cells and that blocking the type I IFN receptor promoted RABV infection.
|
30934732 |
2019 |
|
Spinal Cord Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The most promising results are for interferon beta in human T cell leukaemia virus 1 associated myelopathy/tropical spastic paraparesis and glioma, and for fingolimod in acute ischaemic stroke and intracerebral haemorrhage.
|
31100209 |
2019 |
|
Streptococcal Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
It has been reported that the dominant signaling cascade driving IFN-β in macrophages (MΦ) in streptococcal infection is the cGAS-STING pathway, whereas conventional dendritic cells (DC) exploit endosomal recognition by intracellular TLRs.
|
31732532 |
2019 |
|
Adrenoleukodystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this case study, it is suggested that interferon-β may induce long-term remission in relapsing Schilder disease and is therefore worth considering in this regard.
|
31662417 |
2019 |
|
Memory impairment
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In this study, we examined the effect of IFNβ on memory impairment as well as hippocampal neurogenesis and apoptosis in a rat model of AD.
|
31152860 |
2019 |
|
Human papilloma virus infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Suppression of IFNβ <25 pg/mL was observed in those clearing the HR-HPV infection.
|
30949451 |
2019 |
|
Squamous cell carcinoma of tongue
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study evaluated the potential of GMSCs genetically engineered to produce IFN-β as a targeted gene delivery system to treat tongue squamous cell carcinoma (TSCC) in vitro and in vivo.
|
31358054 |
2019 |
|
Immune thrombocytopenic purpura
|
0.010 |
Biomarker
|
disease |
BEFREE |
In phase two and three clinical trials, the incidence of ITP was higher with alemtuzumab treatment compared to the patients receiving SC IFNB-1a.
|
31720183 |
2019 |
|
Forgetful
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In this study, we examined the effect of IFNβ on memory impairment as well as hippocampal neurogenesis and apoptosis in a rat model of AD.
|
31152860 |
2019 |
|
Equilibration disorder
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The first event occurred in an IFN β-1a-treated patient in association with the initial infusion of IV placebo and consisted of severe balance disorder, dizziness, flushing, and hypoesthesia.
|
30844611 |
2019 |
|
Central Serous Chorioretinopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that the levels of IFN-β and OSM in TNBC dictate the abundance of cells with a CSC phenotype.
|
31036052 |
2019 |
|
ALPHA-THALASSEMIA/MENTAL RETARDATION SYNDROME, NONDELETION TYPE, X-LINKED
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Particularly intriguing are the large N-terminal deletions of ATRX (Alpha Thalassemia/Mental Retardation, X-linked) that generate in-frame fusion (IFF) proteins devoid of key chromatin interaction domains, while retaining the SWI/SNF-like helicase region.
|
31631027 |
2019 |