IFNB1, interferon beta 1, 3456

N. diseases: 426; N. variants: 4
Disease: Mitral Valve Stenosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026269
Disease: Mitral Valve Stenosis
Mitral Valve Stenosis 		0.100 Biomarker disease BEFREE Injection site reactions (ISRs) and influenza-like illness are the most common adverse effects of interferon beta therapies and can present a burden for MS patients leading to non-adherence and discontinuation of therapy. 31202258 2019
CUI: C0026269
Disease: Mitral Valve Stenosis
Mitral Valve Stenosis 		0.100 Biomarker disease BEFREE Interferon beta (IFN-β) benefits patients with MS and reduces symptoms of the RR-MS. MxA is induced by type I interferon and predicts IFN-β response in MS patients. 31421628 2019
CUI: C0026269
Disease: Mitral Valve Stenosis
Mitral Valve Stenosis 		0.100 Biomarker disease BEFREE IFNβ-1a injections will damage qi and cause blood stasis in MS patients, thereby causing various side effects and weakening the body's immune system. 29458918 2018
CUI: C0026269
Disease: Mitral Valve Stenosis
Mitral Valve Stenosis 		0.100 AlteredExpression disease BEFREE Early MRI results and odds of attaining 'no evidence of disease activity' status in MS patients treated with interferon β-1a in the EVIDENCE study. 28716230 2017
CUI: C0026269
Disease: Mitral Valve Stenosis
Mitral Valve Stenosis 		0.100 Biomarker disease BEFREE The humoral immune response to IFN-β observed in MS patients as a result of IFN-β therapy is a multifactorial process that is influenced by ADA titers, affinity maturation, and IgG subclass switching. 28418769 2017
CUI: C0026269
Disease: Mitral Valve Stenosis
Mitral Valve Stenosis 		0.100 Biomarker disease BEFREE This study investigated the influence of HLA class-I and -II genes in the response to IFN-β in relapsing-remitting multiple sclerosis (MS) patients. 27020477 2016
CUI: C0026269
Disease: Mitral Valve Stenosis
Mitral Valve Stenosis 		0.100 Biomarker disease BEFREE Our findings confirmed the lack of association between HLA-DRB1 and clinical response to IFNβ among MS patients as previous studies had done. 25824849 2015
CUI: C0026269
Disease: Mitral Valve Stenosis
Mitral Valve Stenosis 		0.100 AlteredExpression disease BEFREE In this study, IFNβ-1b-treated MS patient gene expression profiles and biological knowledgebases were integrated to study IFNβ's pleiotropic mechanisms of action. 22711062 2013
CUI: C0026269
Disease: Mitral Valve Stenosis
Mitral Valve Stenosis 		0.100 AlteredExpression disease BEFREE R(+)WIN55,212-2 also induces IFN-β expression in MS patient peripheral blood mononuclear cells, whereas down-regulating inflammatory signaling in these cells. 21245146 2011
CUI: C0026269
Disease: Mitral Valve Stenosis
Mitral Valve Stenosis 		0.100 GeneticVariation disease BEFREE An IFNG polymorphism is associated with interferon-beta response in Spanish MS patients. 16430971 2006
CUI: C0026269
Disease: Mitral Valve Stenosis
Mitral Valve Stenosis 		0.100 Biomarker disease BEFREE Persistent neutralizing antibodies abolish the interferon beta bioavailability in MS patients. 12601105 2003