|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
The administration of the R. capsulatus PG lipopolysaccharide was shown to induce interferon-β synthesis, both in healthy and influenza A virus-infected mice, and to promote production of antiviral antibodies in the blood of the influenza-infected animals.
|
31720016 |
2020 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Levels of cytokines, including TNF-α, IL-6, IL-10, and type I IFN (IFN-α and IFN-β), in bronchoalveolar lavage fluid (BALF) were altered after IAV infection; in particular, IFN-α and IFN-β levels were significantly suppressed in the BALF of DIO mice.
|
30967261 |
2019 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these data elucidate that lncRNA ISR is regulated by <i>RIG-I</i>-dependent signaling that governs IFN-β production during IAV infection, and has an inhibitory capacity in viral replication.
|
31623059 |
2019 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In contrast, TLR3-mutated fibroblasts produce lower levels of IFN-β and -λ, and display enhanced viral susceptibility, upon IAV infection.
|
31217193 |
2019 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, unlike IFNAR1, IFNAR2 was sufficient to generate protection from lethal IAV infection when stimulated with IFN-β.
|
30473701 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
IFN-β and IFN-λs were induced in NHNE and ARNE cells up to 3 days after IAV infection.
|
29288502 |
2018 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this chapter, we describe molecular methods for examining necrosome activation in response to the cytokines TNF-α, IFN-β, and IFN-γ, and upon infection with influenza A virus (IAV).
|
30136233 |
2018 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Autophagy diminishes the early interferon-β response to influenza A virus resulting in differential expression of interferon-stimulated genes.
|
29748576 |
2018 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results of the present study demonstrated that mice infected with NS1‑expressing influenza A H1N1 virus had lower expression levels of IFNβ in the lung.
|
28765967 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3.
|
28955326 |
2017 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Influenza A virus non-structural protein 1 (NS1) antagonizes interferon response through diverse strategies, particularly by inhibiting the activation of interferon regulatory factor 3 (IRF3) and IFN-β transcription.
|
28717359 |
2017 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Single-cell studies of IFN-β promoter activation by wild-type and NS1-defective influenza A viruses.
|
27983470 |
2017 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using IFN regulatory factor 3 (IRF3) phosphorylation as a marker of activation of the IFN induction cascade that occurs upstream of the IFN-β promoter, we demonstrate strong activation of the IFN induction cascade in A549 cells infected with a variety of influenza A viruses in the presence of cycloheximide or nucleoprotein (NP) small interfering RNA (siRNA), which inhibits viral protein synthesis and thus complementary ribonucleoprotein (cRNP) and progeny viral RNP (vRNP) synthesis.
|
24478437 |
2014 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Three dimensional analysis of drug-drug interactions revealed that IFN-λ1 interacted with IFN-β and oseltamivir carboxylate in an additive or synergistic manner, respectively, to inhibit influenza A virus replication in human airway epithelial cells.
|
25245230 |
2014 |
|
Influenza A
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, we compared the effect of PB1-F2 variants taken from several IAV strains on IFN-β expression and found that PB1-F2-mediated IFN-β induction is significantly influenced by its amino acid sequence, demonstrating its importance in the host cell response triggered by IAV infection.
|
20844191 |
2010 |