IRGM, immunity related GTPase M, 345611

N. diseases: 57; N. variants: 13
Disease: Paratuberculosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030524
Disease: Paratuberculosis
Paratuberculosis 		0.010 Biomarker disease BEFREE One theoretical link between susceptibility genes NOD2/CARD15, ATG16L1, and IRGM is that CD is primarily induced by the presence of a dysfunctional immunological response to persistent infection by intracellular bacterial pathogens such as Mycobacterium avium subspecies paratuberculosis or adherent-invasive Escherichia coli, both first-rank candidates on the basis of host genetic susceptibility, which concerns impaired functions in the defense against intracellular bacteria. 18726145 2008