|
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that autologous ADSCs improved DNCB-induced AD-like skin lesions in NC/Nga mice by reducing inflammation associated with Th2 immune response and interferon-γ.
|
30688372 |
2019 |
|
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
We aimed to investigate the effects of DHE-Glc, a synthetic molecule derived from ergosterol, on AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) in mice and to elucidate the effects of DHE-Glc on TNF-α/IFN-γ-induced production of CCL17 and CCL22 in human keratinocytes (HaCaTs) and DNCB induced skin inflammation mice model.
|
26100037 |
2015 |
|
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study, we used in situ hybridization to investigate the expression of interleukin 4 (IL-4), IL-5, and interferon-gamma (IFN-gamma) messenger RNA (mRNA) in skin biopsies from acute and chronic skin lesions of patients with AD.
|
8040343 |
1994 |
|
Dermatitis, Atopic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Eight IRF2 SNPs were significantly associated with IFN-γ production after herpes simplex virus (HSV) stimulation (P = 0.048-0.0008), including an AD-associated SNP (rs13139310, P = 0.008).
|
22113474 |
2012 |
|
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These data indicate that in-situ expression of interferon-gamma is linked to the clinical course of atopic dermatitis.
|
7905045 |
1994 |
|
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
An opposite effect was detected upon IFN-γ production in TCD4 cells, such that AD IgG reduced IFN-γ production compared to production under mock conditions but not under IVIG conditions.
|
29355930 |
2018 |
|
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, the imbalance in IL-4 and IFN-gamma secretion in patients with atopic dermatitis may reflect general T cell activation in the presence of an intrinsic defect of IFN-gamma secretion.
|
9199876 |
1997 |
|
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Both AD cohorts showed similarly robust up-regulation of Th2-related (CCL17/18/26) and Th22-related markers (interleukin [IL]-22, S100A8/9/12), but AA AD featured decreased expression of innate immune (tumor necrosis factor [TNF], IL-1β), Th1-related (interferon gamma [IFN-γ], MX1, IL-12RB1), and Th17-related markers (IL-23p19, IL-36G, CXCL1) vs EA AD (P < .05).
|
30223113 |
2019 |
|
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response.
|
21458658 |
2011 |
|
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Decreased frequency of intracellular IFN-gamma producing T cells in whole blood preparations from patients with atopic dermatitis.
|
12473063 |
2002 |
|
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, the lactobacilli isolated from <i>Jeotgal</i> may suppress the development of AD-like skin inflammation in mice by modulating IL-4 and IFN-γ production in CD4<sup>+</sup> T cells, presumably via enhancing IL-12 production by macrophages.
|
28672978 |
2017 |
|
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
AD-MSCs showed an upregulation of many Th1/Th17 cytokines [interleukin (IL)-6, IL-8, IL-12, IL-13, IL-17A, IL-17F, transforming growth factor-β, interferon-γ], while Th2 chemokines (IL-2, IL-4, IL-5, IL-23A) were downregulated in AD-MSCs.
|
27639070 |
2017 |
|
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
We show that miR-146a expression is increased in keratinocytes and chronic lesional skin of patients with AD. miR-146a inhibited the expression of numerous proinflammatory factors, including IFN-γ-inducible and AD-associated genes CCL5, CCL8, and ubiquitin D (UBD) in human primary keratinocytes stimulated with IFN-γ, TNF-α, or IL-1β.
|
24996260 |
2014 |
|
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that CG inhibited the development of the AD-like skin symptoms by modulating Th1 and Th2 responses in the skin lesions in mice and TARC expression by suppressing TNF-α/IFN-γ-induced NF-κB activation in keratinocytes, and so may be a useful tool in the therapy of AD-like skin symptoms.
|
23454147 |
2013 |
|
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Reduced interferon-gamma (IFN-gamma) secretion with increased IFN-gamma mRNA expression in atopic dermatitis: evidence for a post-transcriptional defect.
|
8082304 |
1994 |
|
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Epidermal caspase-3 cleavage associated with interferon-gamma-expressing lymphocytes in acute atopic dermatitis lesions.
|
16689860 |
2006 |
|
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we aimed to investigate whether pCpG-Muγ, a plasmid continuously expressing murine IFN-γ, is an effective treatment of atopic dermatitis, a Th2-dominant skin disease.
|
22914497 |
2013 |
|
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interferon gamma (IFN-γ) has been used treat severe atopic dermatitis, with equivocal results.
|
29144049 |
2017 |
|
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the AD group, the levels of IL-18, IL-4, and IFN-γ in lymphocyte cultures with SEB were significantly increased compared with non-SEB exposed cells (each p<0.001); similar results were found in the control group.
|
27543731 |
2017 |
|
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Human keratinocyte (HaCaT) cells were stimulated with tumor necrosis factor alpha (TNF-α)/IFN-γ to induce AD-like keratinocyte environment.
|
31338033 |
2019 |
|
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
In vitro stimulation with interferon-gamma, a marker cytokine for atopic eczema, induced keratinocyte neurotrophin-4 production, which was able to support growth of a neuroglioblastoma-derived cell line.
|
10844552 |
2000 |
|
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, the decrease of IFN-gamma-producing T lymphocytes in AD is due to a reduction in both Th1 and Tc1 IFN-gamma-secreting cells; this may not only contribute to the over-production of IgE, but also explain the high incidence of cutaneous infections observed in AD patients.
|
9933413 |
1999 |
|
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Increases of general inflammatory (IL-2), innate (IL-1β), and some T<sub>H</sub>1/interferon (IFN-γ) markers in patients with ichthyosis were comparable with those in patients with psoriasis or AD.
|
27554821 |
2017 |
|
Dermatitis, Atopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, treatment with JC3 (10 mg/kg) significantly decreased serum and ear tissues levels of IFN-γ and IL-4 in AD mice.
|
30729380 |
2019 |
|
Dermatitis, Atopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
We demonstrate that keratinocytes of patients with AD exhibit increased IFN-γ-induced apoptosis compared with keratinocytes from healthy subjects.
|
22445417 |
2012 |